The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple transcript variants encoding several different isoforms have been found for this gene. A pseudogene has been identified on the Y chromosome. [provided by RefSeq, Aug 2013]
Transcription factors with Perturb-seq knockdown data for PSMA6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PSMA6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PSMA6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:35,045,870–35,047,118 | 246.1 kb | Distal (>10kb) Multiome | 1047 | |
| chr14:35,121,659–35,123,040 | 170.4 kb | Distal (>10kb) Multiome | 1148 | |
| chr14:35,291,742–35,292,860 | 58 bp | At TSS Multiome | 994 | |
| chr14:35,336,559–35,337,059 | 44.5 kb | Distal (>10kb) Multiome | 773 | |
| chr14:35,341,371–35,342,254 | 49.4 kb | Distal (>10kb) Multiome | 604 | |
| chr14:35,346,777–35,348,358 | 55.6 kb | Distal (>10kb) Multiome | 829 | |
| chr14:35,355,863–35,357,022 | 64.0 kb | Distal (>10kb) Multiome | 595 | |
| chr14:35,403,426–35,405,915 | 112.5 kb | Distal (>10kb) Multiome HiCAR | 1102 | |
| chr14:35,533,170–35,535,985 | 241.6 kb | Distal (>10kb) Multiome | 1111 |
Genomic view of the PSMA6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.