This gene encodes a core alpha subunit of the 20S proteosome, which is a highly ordered ring-shaped structure composed of four rings of 28 non-identical subunits. Proteasomes cleave peptides in an ATP- and ubiquitin-dependent manner. [provided by RefSeq, Aug 2016]
Transcription factors with Perturb-seq knockdown data for PSMA4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PSMA4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PSMA4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:78,264,436–78,265,112 | 275.7 kb | Distal (>10kb) Multiome | 241 | |
| chr15:78,299,130–78,299,874 | 240.8 kb | Distal (>10kb) Multiome | 798 | |
| chr15:78,303,744–78,304,214 | 236.6 kb | Distal (>10kb) Multiome | 287 | |
| chr15:78,340,100–78,340,745 | 200.2 kb | Distal (>10kb) Multiome | 194 | |
| chr15:78,348,106–78,348,824 | 192.0 kb | Distal (>10kb) Multiome | 178 | |
| chr15:78,437,554–78,438,897 | 102.3 kb | Distal (>10kb) Multiome | 918 | |
| chr15:78,506,965–78,508,087 | 33.0 kb | Distal (>10kb) Multiome | 674 | |
| chr15:78,539,941–78,541,020 | 76 bp | At TSS Multiome | 773 | |
| chr15:78,564,790–78,566,388 | 25.1 kb | Distal (>10kb) Multiome | 618 | |
| chr15:78,619,950–78,621,461 | 79.8 kb | Distal (>10kb) Multiome | 274 | |
| chr15:78,640,579–78,641,869 | 100.9 kb | Distal (>10kb) Multiome | 406 | |
| chr15:78,671,569–78,672,301 | 131.5 kb | Distal (>10kb) Multiome | 254 | |
| chr15:78,810,245–78,812,147 | 271.1 kb | Distal (>10kb) Multiome | 505 |
Genomic view of the PSMA4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.