Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PRSS48. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PRSS48 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PRSS48, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:151,014,328–151,016,629 | 261.5 kb | Distal (>10kb) Multiome | 950 | |
| chr4:151,048,986–151,049,930 | 227.5 kb | Distal (>10kb) Multiome | 85 | |
| chr4:151,092,530–151,093,186 | 184.4 kb | Distal (>10kb) Multiome | 32 | |
| chr4:151,098,977–151,100,295 | 177.6 kb | Distal (>10kb) Multiome | 1069 | |
| chr4:151,276,839–151,277,390 | at TSS | At TSS | 149 | |
| chr4:151,284,942–151,285,172 | 7.8 kb | Proximal (<10kb) | 33 | |
| chr4:151,324,320–151,326,042 | 47.4 kb | Distal (>10kb) Multiome | 942 | |
| chr4:151,407,549–151,410,460 | 131.9 kb | Distal (>10kb) Multiome | 800 | |
| chr4:151,488,949–151,490,034 | 212.5 kb | Distal (>10kb) Multiome | 186 |
Genomic view of the PRSS48 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.