This gene encodes a conserved member of the trypsin family of serine proteases. Mouse studies found a decrease of mRNA levels of this gene after ovulation was induced. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Transcription factors with Perturb-seq knockdown data for PRSS23. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PRSS23 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PRSS23, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:86,374,442–86,374,974 | 425.7 kb | Distal (>10kb) Multiome HiCAR | 124 | |
| chr11:86,421,815–86,422,714 | 378.3 kb | Distal (>10kb) Multiome HiCAR | 141 | |
| chr11:86,422,902–86,424,146 | 376.8 kb | Distal (>10kb) Multiome HiCAR | 152 | |
| chr11:86,513,467–86,514,411 | 286.6 kb | Distal (>10kb) Multiome HiCAR | 148 | |
| chr11:86,571,370–86,571,978 | 228.8 kb | Distal (>10kb) Multiome HiCAR | 310 | |
| chr11:86,671,463–86,672,739 | 128.3 kb | Distal (>10kb) Multiome HiCAR | 467 | |
| chr11:86,799,108–86,799,430 | 1.1 kb | Proximal (<10kb) | 64 | |
| chr11:86,799,611–86,801,237 | 80 bp | At TSS Multiome | 470 | |
| chr11:86,801,347–86,801,538 | 827 bp | At TSS | 57 | |
| chr11:86,802,636–86,803,057 | 2.1 kb | Proximal (<10kb) | 214 | |
| chr11:86,807,432–86,807,688 | 6.9 kb | Proximal (<10kb) | 34 | |
| chr11:86,923,773–86,924,364 | 123.7 kb | Distal (>10kb) Multiome | 296 | |
| chr11:86,954,420–86,956,821 | 155.1 kb | Distal (>10kb) Multiome | 987 | |
| chr11:86,996,771–86,997,659 | 196.6 kb | Distal (>10kb) Multiome | 144 | |
| chr11:86,999,558–87,000,730 | 199.9 kb | Distal (>10kb) Multiome | 620 | |
| chr11:87,037,068–87,038,477 | 237.3 kb | Distal (>10kb) Multiome | 959 |
Genomic view of the PRSS23 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.