Enables WW domain binding activity. Predicted to be involved in blood coagulation. Located in plasma membrane. Biomarker of cholangiocarcinoma. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PRRG4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PRRG4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PRRG4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:32,583,226–32,584,622 | 246.2 kb | Distal (>10kb) Multiome | 913 | |
| chr11:32,829,540–32,830,458 | 48 bp | At TSS Multiome | 566 | |
| chr11:32,891,344–32,894,653 | 62.9 kb | Distal (>10kb) Multiome | 1040 | |
| chr11:33,015,524–33,016,542 | 186.0 kb | Distal (>10kb) Multiome | 837 | |
| chr11:33,038,936–33,040,258 | 209.5 kb | Distal (>10kb) Multiome | 917 |
Genomic view of the PRRG4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.