The protein encoded by this gene tethers heterochromatin to the nuclear laminar scaffold by binding heterochromatin protein 1 (HP1) and the nuclear lamina. The tether is broken during mitosis and reforms quickly after mitosis, with the encoded protein first binding HP1 and then attaching to the nuclear lamina. This protein also has been shown to promote MyoD activity and skeletal myogenesis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2016]
Transcription factors with Perturb-seq knockdown data for PRR14. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PRR14 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PRR14, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:30,354,854–30,355,978 | 295.3 kb | Distal (>10kb) Multiome | 1070 | |
| chr16:30,369,220–30,371,611 | 280.0 kb | Distal (>10kb) Multiome | 818 | |
| chr16:30,377,495–30,379,532 | 272.4 kb | Distal (>10kb) Multiome | 1025 | |
| chr16:30,394,422–30,396,098 | 255.5 kb | Distal (>10kb) Multiome | 941 | |
| chr16:30,400,026–30,401,048 | 250.2 kb | Distal (>10kb) Multiome | 839 | |
| chr16:30,406,974–30,408,429 | 243.2 kb | Distal (>10kb) Multiome | 908 | |
| chr16:30,417,414–30,418,576 | 232.6 kb | Distal (>10kb) Multiome | 543 | |
| chr16:30,429,571–30,430,773 | 220.5 kb | Distal (>10kb) Multiome HiCAR | 1060 | |
| chr16:30,445,340–30,446,062 | 204.9 kb | Distal (>10kb) Multiome | 898 | |
| chr16:30,526,068–30,527,896 | 123.3 kb | Distal (>10kb) Multiome | 1004 | |
| chr16:30,534,370–30,535,460 | 115.8 kb | Distal (>10kb) Multiome | 957 | |
| chr16:30,557,913–30,558,847 | 92.2 kb | Distal (>10kb) Multiome | 1025 | |
| chr16:30,571,001–30,572,505 | 78.7 kb | Distal (>10kb) Multiome | 950 | |
| chr16:30,585,243–30,586,223 | 64.9 kb | Distal (>10kb) Multiome | 588 | |
| chr16:30,609,586–30,610,748 | 40.3 kb | Distal (>10kb) Multiome | 1030 | |
| chr16:30,634,070–30,634,986 | 16.3 kb | Distal (>10kb) Multiome | 907 | |
| chr16:30,650,029–30,651,831 | 4 bp | At TSS Multiome | 992 | |
| chr16:30,657,638–30,659,894 | 7.6 kb | Proximal (<10kb) Multiome | 1053 | |
| chr16:30,677,814–30,678,622 | 27.5 kb | Distal (>10kb) Multiome | 177 | |
| chr16:30,697,755–30,699,614 | 48.4 kb | Distal (>10kb) Multiome | 1153 | |
| chr16:30,747,864–30,748,943 | 97.6 kb | Distal (>10kb) Multiome | 824 | |
| chr16:30,761,380–30,762,606 | 111.5 kb | Distal (>10kb) Multiome | 885 | |
| chr16:30,774,965–30,776,186 | 124.8 kb | Distal (>10kb) Multiome | 1025 | |
| chr16:30,786,385–30,788,019 | 136.5 kb | Distal (>10kb) Multiome | 885 | |
| chr16:30,805,468–30,806,187 | 155.0 kb | Distal (>10kb) Multiome | 969 | |
| chr16:30,814,045–30,814,733 | 163.7 kb | Distal (>10kb) Multiome | 995 | |
| chr16:30,841,062–30,841,882 | 190.9 kb | Distal (>10kb) Multiome | 49 | |
| chr16:30,874,866–30,875,643 | 224.6 kb | Distal (>10kb) Multiome | 1108 | |
| chr16:30,893,485–30,894,587 | 243.5 kb | Distal (>10kb) Multiome | 950 | |
| chr16:30,895,854–30,897,426 | 246.3 kb | Distal (>10kb) Multiome | 822 | |
| chr16:30,901,969–30,902,794 | 251.6 kb | Distal (>10kb) Multiome | 579 | |
| chr16:30,921,611–30,925,097 | 272.7 kb | Distal (>10kb) Multiome | 1132 | |
| chr16:30,927,705–30,928,596 | 277.4 kb | Distal (>10kb) Multiome | 274 | |
| chr16:30,941,803–30,942,254 | 291.4 kb | Distal (>10kb) Multiome | 507 | |
| chr16:30,947,471–30,950,635 | 299.5 kb | Distal (>10kb) Multiome | 1066 |
Genomic view of the PRR14 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.