This gene encodes a proline-rich protein that contains two A-T hook DNA binding domains. A chromosomal translocation and gene fusion between this gene and zinc finger, MIZ-type containing 1 (Gene ID: 57178) may underlie intellectual disability and neuropsychiatric problems in a human patient. Enriched expression of this gene in embryonic mouse brain suggests that this gene may play a role in nervous system development. [provided by RefSeq, Jul 2016]
Transcription factors with Perturb-seq knockdown data for PRR12. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PRR12 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PRR12, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:49,337,997–49,340,482 | 252.0 kb | Distal (>10kb) Multiome | 612 | |
| chr19:49,361,283–49,362,837 | 229.6 kb | Distal (>10kb) Multiome | 553 | |
| chr19:49,362,970–49,364,306 | 227.5 kb | Distal (>10kb) Multiome | 616 | |
| chr19:49,403,611–49,404,247 | 187.2 kb | Distal (>10kb) Multiome | 305 | |
| chr19:49,432,343–49,432,785 | 158.7 kb | Distal (>10kb) Multiome | 103 | |
| chr19:49,436,149–49,436,821 | 154.7 kb | Distal (>10kb) Multiome | 248 | |
| chr19:49,441,067–49,441,861 | 149.7 kb | Distal (>10kb) Multiome | 223 | |
| chr19:49,442,072–49,444,054 | 148.2 kb | Distal (>10kb) Multiome | 914 | |
| chr19:49,451,347–49,452,239 | 139.3 kb | Distal (>10kb) Multiome | 764 | |
| chr19:49,452,723–49,453,850 | 137.8 kb | Distal (>10kb) Multiome | 847 | |
| chr19:49,476,063–49,476,551 | 114.8 kb | Distal (>10kb) Multiome | 244 | |
| chr19:49,487,027–49,488,279 | 103.8 kb | Distal (>10kb) Multiome | 964 | |
| chr19:49,495,613–49,496,661 | 95.0 kb | Distal (>10kb) Multiome | 919 | |
| chr19:49,500,403–49,501,353 | 90.5 kb | Distal (>10kb) Multiome | 405 | |
| chr19:49,512,565–49,513,700 | 78.1 kb | Distal (>10kb) Multiome | 655 | |
| chr19:49,527,651–49,528,221 | 63.2 kb | Distal (>10kb) Multiome | 354 | |
| chr19:49,533,232–49,534,476 | 57.1 kb | Distal (>10kb) Multiome | 534 | |
| chr19:49,555,629–49,557,180 | 35.0 kb | Distal (>10kb) Multiome | 294 | |
| chr19:49,580,125–49,580,813 | 10.6 kb | Distal (>10kb) Multiome | 848 | |
| chr19:49,589,601–49,594,008 | 2.4 kb | Proximal (<10kb) Multiome | 994 | |
| chr19:49,638,063–49,638,728 | 47.1 kb | Distal (>10kb) Multiome | 237 | |
| chr19:49,639,671–49,642,787 | 49.2 kb | Distal (>10kb) Multiome | 1067 | |
| chr19:49,664,165–49,665,096 | 73.3 kb | Distal (>10kb) Multiome | 679 | |
| chr19:49,665,345–49,666,430 | 74.7 kb | Distal (>10kb) Multiome | 721 | |
| chr19:49,672,105–49,672,787 | 81.2 kb | Distal (>10kb) Multiome | 625 | |
| chr19:49,676,058–49,678,754 | 85.8 kb | Distal (>10kb) Multiome | 1033 | |
| chr19:49,680,433–49,681,147 | 89.6 kb | Distal (>10kb) Multiome | 435 | |
| chr19:49,690,485–49,691,761 | 99.9 kb | Distal (>10kb) Multiome | 327 | |
| chr19:49,746,188–49,746,748 | 155.3 kb | Distal (>10kb) Multiome | 283 | |
| chr19:49,766,231–49,767,440 | 175.5 kb | Distal (>10kb) Multiome | 718 | |
| chr19:49,802,146–49,802,787 | 211.3 kb | Distal (>10kb) Multiome | 200 | |
| chr19:49,805,226–49,805,871 | 214.4 kb | Distal (>10kb) Multiome | 245 | |
| chr19:49,808,201–49,809,746 | 217.8 kb | Distal (>10kb) Multiome | 509 | |
| chr19:49,812,926–49,813,834 | 222.3 kb | Distal (>10kb) Multiome | 650 | |
| chr19:49,817,356–49,818,721 | 227.0 kb | Distal (>10kb) Multiome | 784 | |
| chr19:49,850,394–49,852,067 | 259.7 kb | Distal (>10kb) Multiome | 862 | |
| chr19:49,866,817–49,868,124 | 276.2 kb | Distal (>10kb) Multiome | 874 | |
| chr19:49,869,068–49,870,398 | 278.5 kb | Distal (>10kb) Multiome | 832 | |
| chr19:49,875,842–49,878,576 | 286.6 kb | Distal (>10kb) Multiome | 1153 | |
| chr19:49,889,853–49,891,381 | 299.3 kb | Distal (>10kb) Multiome | 640 |
Genomic view of the PRR12 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.