Enables ribonuclease P activity. Involved in mitochondrial tRNA 5'-end processing. Located in mitochondrion and nucleoplasm. Part of mitochondrial ribonuclease P complex. Implicated in combined oxidative phosphorylation deficiency 54. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PRORP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PRORP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PRORP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:34,873,262–34,875,515 | 247.3 kb | Distal (>10kb) Multiome | 1146 | |
| chr14:34,981,885–34,983,443 | 139.8 kb | Distal (>10kb) Multiome | 1124 | |
| chr14:35,045,870–35,047,118 | 76.3 kb | Distal (>10kb) Multiome | 1047 | |
| chr14:35,113,020–35,113,353 | 9.2 kb | Proximal (<10kb) | 15 | |
| chr14:35,113,458–35,113,896 | 8.6 kb | Proximal (<10kb) | 44 | |
| chr14:35,121,659–35,123,040 | 553 bp | At TSS Multiome | 1148 | |
| chr14:35,291,742–35,292,860 | 169.7 kb | Distal (>10kb) Multiome | 994 | |
| chr14:35,336,559–35,337,059 | 214.3 kb | Distal (>10kb) Multiome | 773 | |
| chr14:35,341,371–35,342,254 | 219.2 kb | Distal (>10kb) Multiome | 604 | |
| chr14:35,346,777–35,348,358 | 225.4 kb | Distal (>10kb) Multiome | 829 | |
| chr14:35,355,863–35,357,022 | 233.8 kb | Distal (>10kb) Multiome | 595 | |
| chr14:35,403,426–35,405,915 | 282.3 kb | Distal (>10kb) Multiome HiCAR | 1102 |
Genomic view of the PRORP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.