The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy. The encoded protein may also play a role in malarial infection and has been associated with cancer. [provided by RefSeq, Jul 2013]
Transcription factors with Perturb-seq knockdown data for PROCR. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PROCR upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PROCR, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:34,872,384–34,873,259 | 299.2 kb | Distal (>10kb) Multiome | 817 | |
| chr20:34,875,878–34,877,081 | 295.7 kb | Distal (>10kb) Multiome | 852 | |
| chr20:34,955,039–34,956,224 | 216.2 kb | Distal (>10kb) Multiome | 1031 | |
| chr20:34,979,568–34,980,289 | 192.1 kb | Distal (>10kb) Multiome | 149 | |
| chr20:35,092,320–35,093,398 | 79.2 kb | Distal (>10kb) Multiome | 1139 | |
| chr20:35,146,563–35,147,734 | 24.8 kb | Distal (>10kb) Multiome | 992 | |
| chr20:35,171,731–35,172,358 | 86 bp | At TSS Multiome | 383 | |
| chr20:35,174,680–35,175,277 | 2.9 kb | Proximal (<10kb) Multiome | 635 | |
| chr20:35,262,839–35,263,582 | 91.3 kb | Distal (>10kb) Multiome | 336 | |
| chr20:35,269,197–35,269,766 | 97.4 kb | Distal (>10kb) Multiome | 447 | |
| chr20:35,277,415–35,278,519 | 106.0 kb | Distal (>10kb) Multiome | 575 | |
| chr20:35,284,235–35,285,360 | 112.7 kb | Distal (>10kb) Multiome | 950 | |
| chr20:35,303,859–35,304,479 | 132.0 kb | Distal (>10kb) Multiome | 484 | |
| chr20:35,454,521–35,455,845 | 283.1 kb | Distal (>10kb) Multiome | 1059 |
Genomic view of the PROCR locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.