This gene encodes a type II methyltransferase. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to the guanidino nitrogen atoms of arginine. The protein encoded by this gene methylates spliceosome associated protein 145 to regulate alternative splicing and acts as a modulator of small nuclear ribonucleoprotein maturation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2017]
Transcription factors with Perturb-seq knockdown data for PRMT9. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PRMT9 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PRMT9, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:147,480,463–147,482,217 | 202.9 kb | Distal (>10kb) Multiome | 379 | |
| chr4:147,522,274–147,523,482 | 161.1 kb | Distal (>10kb) Multiome | 84 | |
| chr4:147,616,952–147,618,103 | 66.7 kb | Distal (>10kb) Multiome | 744 | |
| chr4:147,679,213–147,679,479 | 4.6 kb | Proximal (<10kb) | 77 | |
| chr4:147,683,720–147,684,759 | 42 bp | At TSS Multiome | 824 | |
| chr4:147,730,889–147,733,228 | 48.0 kb | Distal (>10kb) Multiome | 724 | |
| chr4:147,924,252–147,925,592 | 240.9 kb | Distal (>10kb) Multiome | 282 |
Genomic view of the PRMT9 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.