This gene encodes an enzyme that belongs to the methyltransferase family. The encoded protein catalyzes the transfer of methyl groups to the amino acid arginine, in target proteins that include histones, transcriptional elongation factors and the tumor suppressor p53. This gene plays a role in several cellular processes, including transcriptional regulation, and the assembly of small nuclear ribonucleoproteins. A pseudogene of this gene has been defined on chromosome 4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]
Transcription factors with Perturb-seq knockdown data for PRMT5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PRMT5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PRMT5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:22,766,419–22,767,375 | 162.7 kb | Distal (>10kb) Multiome | 988 | |
| chr14:22,821,826–22,823,530 | 106.5 kb | Distal (>10kb) Multiome | 649 | |
| chr14:22,829,704–22,830,328 | 99.4 kb | Distal (>10kb) Multiome | 871 | |
| chr14:22,836,107–22,837,017 | 92.9 kb | Distal (>10kb) Multiome | 320 | |
| chr14:22,852,845–22,853,709 | 76.1 kb | Distal (>10kb) Multiome | 788 | |
| chr14:22,870,967–22,873,202 | 57.8 kb | Distal (>10kb) Multiome | 1167 | |
| chr14:22,882,594–22,883,886 | 46.2 kb | Distal (>10kb) Multiome | 289 | |
| chr14:22,886,371–22,887,824 | 42.2 kb | Distal (>10kb) Multiome | 639 | |
| chr14:22,918,527–22,919,975 | 10.0 kb | Distal (>10kb) Multiome | 641 | |
| chr14:22,928,961–22,930,849 | 139 bp | At TSS Multiome | 1108 | |
| chr14:22,933,450–22,933,927 | 4.1 kb | Proximal (<10kb) | 16 | |
| chr14:22,956,530–22,957,512 | 27.7 kb | Distal (>10kb) Multiome | 983 | |
| chr14:22,981,215–22,983,249 | 53.3 kb | Distal (>10kb) Multiome | 935 | |
| chr14:23,006,674–23,007,583 | 77.8 kb | Distal (>10kb) Multiome | 1097 | |
| chr14:23,020,642–23,021,291 | 91.6 kb | Distal (>10kb) Multiome | 148 | |
| chr14:23,101,326–23,101,861 | 172.2 kb | Distal (>10kb) Multiome | 83 | |
| chr14:23,154,159–23,154,639 | 225.1 kb | Distal (>10kb) Multiome | 392 | |
| chr14:23,161,040–23,161,530 | 232.0 kb | Distal (>10kb) Multiome | 397 | |
| chr14:23,182,495–23,182,942 | 253.4 kb | Distal (>10kb) Multiome | 139 |
Genomic view of the PRMT5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.