PRMT1
protein arginine methyltransferase 1 | ANM1, HCP1, HRMT1L2

This gene encodes a member of the protein arginine N-methyltransferase (PRMT) family. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to terminal guanidino nitrogen atoms. The encoded protein is a type I PRMT and is responsible for the majority of cellular arginine methylation activity. Increased expression of this gene may play a role in many types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2011]

Member of: DE-1 DE-1.24
Biological processes 74 terms
DNA damage response (GO:0006974)GATOR1 complex binding (GO:0106080)N-methyltransferase activity (GO:0008170)N-methyltransferase activity (GO:0008170)N-methyltransferase activity (GO:0008170)RNA binding (GO:0003723)RNA splicing (GO:0008380)S-adenosyl-L-methionine binding (GO:1904047)S-adenosyl-L-methionine binding (GO:1904047)arginine N-methyltransferase activity (GO:0016273)cardiac muscle tissue development (GO:0048738)cell surface receptor signaling pathway (GO:0007166)cellular response to methionine (GO:0061431)cellular response to methionine (GO:0061431)chromatin remodeling (GO:0006338)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)enzyme binding (GO:0019899)histone H4 methyltransferase activity (GO:0140939)histone H4R3 methyltransferase activity (GO:0044020)histone H4R3 methyltransferase activity (GO:0044020)histone methyltransferase activity (GO:0042054)histone methyltransferase activity (GO:0042054)identical protein binding (GO:0042802)identical protein binding (GO:0042802)lysosomal membrane (GO:0005765)lysosomal membrane (GO:0005765)methyl-CpG binding (GO:0008327)methylosome (GO:0034709)methyltransferase activity (GO:0008168)mitogen-activated protein kinase p38 binding (GO:0048273)negative regulation of JNK cascade (GO:0046329)negative regulation of apoptotic process (GO:0043066)negative regulation of megakaryocyte differentiation (GO:0045653)neuron projection development (GO:0031175)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of TORC1 signaling (GO:1904263)positive regulation of TORC1 signaling (GO:1904263)positive regulation of double-strand break repair via homologous recombination (GO:1905168)positive regulation of erythrocyte differentiation (GO:0045648)positive regulation of hemoglobin biosynthetic process (GO:0046985)positive regulation of p38MAPK cascade (GO:1900745)positive regulation of translation (GO:0045727)protein binding (GO:0005515)protein homooligomerization (GO:0051260)protein methyltransferase activity (GO:0008276)protein methyltransferase activity (GO:0008276)protein methyltransferase activity (GO:0008276)protein-arginine N-methyltransferase activity (GO:0016274)protein-arginine N-methyltransferase activity (GO:0016274)protein-arginine N-methyltransferase activity (GO:0016274)protein-arginine N-methyltransferase activity (GO:0016274)protein-arginine N-methyltransferase activity (GO:0016274)protein-arginine omega-N asymmetric methyltransferase activity (GO:0035242)protein-arginine omega-N asymmetric methyltransferase activity (GO:0035242)protein-arginine omega-N asymmetric methyltransferase activity (GO:0035242)protein-arginine omega-N asymmetric methyltransferase activity (GO:0035242)protein-arginine omega-N asymmetric methyltransferase activity (GO:0035242)protein-arginine omega-N monomethyltransferase activity (GO:0035241)protein-arginine omega-N monomethyltransferase activity (GO:0035241)protein-arginine omega-N monomethyltransferase activity (GO:0035241)regulation of BMP signaling pathway (GO:0030510)regulation of DNA-templated transcription (GO:0006355)regulation of megakaryocyte differentiation (GO:0045652)regulation of megakaryocyte differentiation (GO:0045652)viral protein processing (GO:0019082)
Expression (TPM)
PRMT1 — as a Regulated Gene

TFs regulating PRMT1 0 TFs

Transcription factors with Perturb-seq knockdown data for PRMT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PRMT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to PRMT1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PRMT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr19:49,403,611–49,404,247 273.3 kb Distal (>10kb) Multiome 305
chr19:49,432,343–49,432,785 244.7 kb Distal (>10kb) Multiome 103
chr19:49,436,149–49,436,821 240.7 kb Distal (>10kb) Multiome 248
chr19:49,441,067–49,441,861 235.7 kb Distal (>10kb) Multiome 223
chr19:49,442,072–49,444,054 234.3 kb Distal (>10kb) Multiome 914
chr19:49,451,347–49,452,239 225.4 kb Distal (>10kb) Multiome 764
chr19:49,452,723–49,453,850 223.9 kb Distal (>10kb) Multiome 847
chr19:49,476,063–49,476,551 200.9 kb Distal (>10kb) Multiome 244
chr19:49,487,027–49,488,279 189.8 kb Distal (>10kb) Multiome 964
chr19:49,495,613–49,496,661 181.0 kb Distal (>10kb) Multiome 919
chr19:49,500,403–49,501,353 176.5 kb Distal (>10kb) Multiome 405
chr19:49,512,565–49,513,700 164.2 kb Distal (>10kb) Multiome 655
chr19:49,527,651–49,528,221 149.3 kb Distal (>10kb) Multiome 354
chr19:49,533,232–49,534,476 143.2 kb Distal (>10kb) Multiome 534
chr19:49,555,629–49,557,180 121.1 kb Distal (>10kb) Multiome 294
chr19:49,580,125–49,580,813 96.6 kb Distal (>10kb) Multiome 848
chr19:49,589,601–49,594,008 83.7 kb Distal (>10kb) Multiome 994
chr19:49,638,063–49,638,728 39.0 kb Distal (>10kb) Multiome 237
chr19:49,639,671–49,642,787 36.8 kb Distal (>10kb) Multiome 1067
chr19:49,664,165–49,665,096 12.7 kb Distal (>10kb) Multiome 679
chr19:49,665,345–49,666,430 11.3 kb Distal (>10kb) Multiome 721
chr19:49,672,105–49,672,787 4.8 kb Proximal (<10kb) Multiome 625
chr19:49,675,666–49,675,902 1.3 kb Proximal (<10kb) 84
chr19:49,676,058–49,678,754 308 bp At TSS Multiome 1033
chr19:49,680,433–49,681,147 3.5 kb Proximal (<10kb) Multiome 435
chr19:49,690,485–49,691,761 13.9 kb Distal (>10kb) Multiome 327
chr19:49,746,188–49,746,748 69.2 kb Distal (>10kb) Multiome 283
chr19:49,766,231–49,767,440 89.4 kb Distal (>10kb) Multiome 718
chr19:49,802,146–49,802,787 125.2 kb Distal (>10kb) Multiome 200
chr19:49,805,226–49,805,871 128.3 kb Distal (>10kb) Multiome 245
chr19:49,808,201–49,809,746 131.7 kb Distal (>10kb) Multiome 509
chr19:49,812,926–49,813,834 136.2 kb Distal (>10kb) Multiome 650
chr19:49,817,356–49,818,721 141.0 kb Distal (>10kb) Multiome 784
chr19:49,850,394–49,852,067 173.6 kb Distal (>10kb) Multiome 862
chr19:49,866,817–49,868,124 190.1 kb Distal (>10kb) Multiome 874
chr19:49,869,068–49,870,398 192.4 kb Distal (>10kb) Multiome 832
chr19:49,875,842–49,878,576 200.5 kb Distal (>10kb) Multiome 1153
chr19:49,889,853–49,891,381 213.2 kb Distal (>10kb) Multiome 640
chr19:49,928,884–49,930,473 252.7 kb Distal (>10kb) Multiome 1141

Genome Browser

Genomic view of the PRMT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr19:49,393,611 – 49,940,473
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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