This gene belongs to the multigene protein kinase D family of serine/threonine kinases, which bind diacylglycerol and phorbol esters. Members of this family are characterized by an N-terminal regulatory domain comprised of a tandem repeat of cysteine-rich zinc-finger motifs and a pleckstrin domain. The C-terminal region contains the catalytic domain and is distantly related to calcium-regulated kinases. Catalytic activity of this enzyme promotes its nuclear localization. This protein has been implicated in a variety of functions including negative regulation of human airway epithelial barrier formation, growth regulation of breast and prostate cancer cells, and vesicle trafficking. [provided by RefSeq, Jan 2015]
Transcription factors with Perturb-seq knockdown data for PRKD3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PRKD3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PRKD3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:37,083,780–37,086,187 | 239.0 kb | Distal (>10kb) Multiome | 938 | |
| chr2:37,156,055–37,157,536 | 167.8 kb | Distal (>10kb) Multiome | 702 | |
| chr2:37,205,153–37,205,870 | 119.4 kb | Distal (>10kb) Multiome | 157 | |
| chr2:37,231,272–37,232,043 | 93.2 kb | Distal (>10kb) Multiome | 891 | |
| chr2:37,305,706–37,306,783 | 18.7 kb | Distal (>10kb) Multiome | 129 | |
| chr2:37,323,791–37,325,583 | 18 bp | At TSS Multiome | 835 | |
| chr2:37,443,019–37,443,805 | 118.6 kb | Distal (>10kb) Multiome | 55 | |
| chr2:37,535,945–37,536,470 | 211.4 kb | Distal (>10kb) Multiome | 211 |
Genomic view of the PRKD3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.