This gene encodes a homolog of Drosophila prickle. The exact function of this gene is not known, however, studies in mice suggest that it may be involved in seizure prevention. Mutations in this gene are associated with progressive myoclonic epilepsy type 5. [provided by RefSeq, Dec 2011]
Transcription factors with Perturb-seq knockdown data for PRICKLE2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PRICKLE2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PRICKLE2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:64,023,033–64,023,678 | 202.0 kb | Distal (>10kb) Multiome HiCAR | 925 | |
| chr3:64,030,557–64,031,016 | 194.6 kb | Distal (>10kb) Multiome HiCAR | 509 | |
| chr3:64,063,306–64,064,385 | 161.6 kb | Distal (>10kb) Multiome | 142 | |
| chr3:64,267,687–64,268,494 | 42.6 kb | Distal (>10kb) Multiome | 241 | |
| chr3:64,444,744–64,445,851 | 220.0 kb | Distal (>10kb) Multiome | 328 | |
| chr3:64,489,031–64,490,029 | 264.1 kb | Distal (>10kb) Multiome HiCAR | 232 | |
| chr3:64,649,591–64,650,867 | 424.7 kb | Distal (>10kb) Multiome | 252 | |
| chr3:64,684,758–64,686,900 | 460.6 kb | Distal (>10kb) Multiome | 510 | |
| chr3:64,687,325–64,689,155 | 462.5 kb | Distal (>10kb) Multiome | 398 |
Genomic view of the PRICKLE2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.