This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein interacts with peroxisome receptor 1 and plays an antioxidant protective role in different tissues under normal conditions and during inflammatory processes. The use of alternate transcription start sites is thought to result in transcript variants that use different in-frame translational start codons to generate isoforms that are targeted to the mitochondrion (isoform L) or peroxisome/cytoplasm (isoform S). Multiple related pseudogenes have been defined for this gene. [provided by RefSeq, Nov 2017]
Transcription factors with Perturb-seq knockdown data for PRDX5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PRDX5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PRDX5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:64,028,126–64,028,898 | 289.5 kb | Distal (>10kb) Multiome | 168 | |
| chr11:64,165,638–64,166,698 | 151.9 kb | Distal (>10kb) Multiome | 811 | |
| chr11:64,184,927–64,186,817 | 132.2 kb | Distal (>10kb) Multiome | 1091 | |
| chr11:64,225,548–64,226,862 | 91.9 kb | Distal (>10kb) Multiome | 776 | |
| chr11:64,230,074–64,231,130 | 87.6 kb | Distal (>10kb) Multiome | 715 | |
| chr11:64,233,950–64,235,296 | 83.6 kb | Distal (>10kb) Multiome | 590 | |
| chr11:64,240,398–64,242,687 | 76.8 kb | Distal (>10kb) Multiome | 982 | |
| chr11:64,246,274–64,248,065 | 71.0 kb | Distal (>10kb) Multiome | 802 | |
| chr11:64,250,699–64,251,842 | 66.7 kb | Distal (>10kb) Multiome | 498 | |
| chr11:64,268,509–64,270,920 | 48.0 kb | Distal (>10kb) Multiome | 1093 | |
| chr11:64,271,352–64,271,994 | 46.5 kb | Distal (>10kb) Multiome | 595 | |
| chr11:64,284,095–64,286,666 | 32.4 kb | Distal (>10kb) Multiome | 807 | |
| chr11:64,300,129–64,301,268 | 17.1 kb | Distal (>10kb) Multiome | 591 | |
| chr11:64,304,032–64,307,072 | 11.7 kb | Distal (>10kb) Multiome | 994 | |
| chr11:64,316,954–64,319,418 | 921 bp | At TSS Multiome | 1039 | |
| chr11:64,340,711–64,341,211 | 22.8 kb | Distal (>10kb) Multiome | 212 | |
| chr11:64,342,083–64,343,227 | 24.6 kb | Distal (>10kb) Multiome | 543 | |
| chr11:64,358,792–64,359,751 | 41.0 kb | Distal (>10kb) Multiome | 577 | |
| chr11:64,448,870–64,449,995 | 130.9 kb | Distal (>10kb) Multiome | 490 |
Genomic view of the PRDX5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.