The protein encoded by this gene is an antioxidant enzyme and belongs to the peroxiredoxin family. The protein is localized to the cytoplasm. Peroxidases of the peroxiredoxin family reduce hydrogen peroxide and alkyl hydroperoxides to water and alcohol with the use of reducing equivalents derived from thiol-containing donor molecules. This protein has been found to play a regulatory role in the activation of the transcription factor NF-kappaB. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PRDX4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PRDX4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PRDX4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:23,660,186–23,660,759 | 6.7 kb | Proximal (<10kb) | 16 | |
| chrX:23,667,233–23,667,983 | 13 bp | At TSS Multiome | 695 | |
| chrX:23,742,772–23,743,685 | 75.8 kb | Distal (>10kb) Multiome | 635 | |
| chrX:23,782,718–23,783,632 | 115.6 kb | Distal (>10kb) Multiome | 741 | |
| chrX:23,907,232–23,908,257 | 240.4 kb | Distal (>10kb) Multiome | 770 |
Genomic view of the PRDX4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.