Transcription factors with Perturb-seq knockdown data for PRDM6-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PRDM6-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PRDM6-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:123,086,419–123,087,572 | 1.7 kb | Proximal (<10kb) | 145 | |
| chr5:123,088,080–123,091,125 | at TSS | At TSS | 570 | |
| chr5:123,092,728–123,093,098 | 3.4 kb | Proximal (<10kb) | 26 | |
| chr5:123,093,515–123,094,439 | 4.2 kb | Proximal (<10kb) | 126 | |
| chr5:123,094,668–123,096,016 | 5.4 kb | Proximal (<10kb) | 186 | |
| chr5:123,097,777–123,100,237 | 8.5 kb | Proximal (<10kb) | 307 |
Genomic view of the PRDM6-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.