Predicted to enable histone methyltransferase activity. Predicted to be involved in regulation of gene expression. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II and neurogenesis. Predicted to be active in nucleus. Implicated in pontocerebellar hypoplasia. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PRDM13. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PRDM13 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PRDM13, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:99,602,753–99,604,086 | 2.7 kb | Proximal (<10kb) | 376 | |
| chr6:99,604,755–99,605,078 | 1.8 kb | Proximal (<10kb) | 41 | |
| chr6:99,605,178–99,605,653 | 1.2 kb | Proximal (<10kb) | 92 | |
| chr6:99,606,604–99,607,477 | at TSS | At TSS | 140 | |
| chr6:99,607,682–99,608,664 | 850 bp | At TSS | 63 | |
| chr6:99,612,582–99,615,086 | 5.8 kb | Proximal (<10kb) | 533 |
Genomic view of the PRDM13 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.