This gene encodes a protein that may play a role in pre-mRNA splicing. Chromosomal translocations (X;1)(p11;q21) that result in fusion of this gene to TFE3 (GeneID 7030) have been associated with papillary renal cell carcinoma. A PRCC-TFE3 fusion protein is expressed in affected carcinomas and is likely associated with altered gene transactivation. This fusion protein has also been associated with disruption of the cell cycle.[provided by RefSeq, Aug 2010]
Transcription factors with Perturb-seq knockdown data for PRCC. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PRCC upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PRCC, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:156,499,927–156,501,599 | 266.6 kb | Distal (>10kb) Multiome | 950 | |
| chr1:156,504,626–156,505,685 | 262.2 kb | Distal (>10kb) Multiome | 911 | |
| chr1:156,572,298–156,572,749 | 195.0 kb | Distal (>10kb) Multiome | 580 | |
| chr1:156,583,883–156,584,356 | 183.4 kb | Distal (>10kb) Multiome | 183 | |
| chr1:156,591,252–156,592,285 | 175.7 kb | Distal (>10kb) Multiome | 706 | |
| chr1:156,601,188–156,601,796 | 166.0 kb | Distal (>10kb) Multiome | 759 | |
| chr1:156,624,123–156,624,848 | 143.0 kb | Distal (>10kb) Multiome | 472 | |
| chr1:156,641,772–156,642,623 | 125.4 kb | Distal (>10kb) Multiome | 211 | |
| chr1:156,657,279–156,657,727 | 110.0 kb | Distal (>10kb) Multiome | 357 | |
| chr1:156,659,788–156,660,816 | 107.3 kb | Distal (>10kb) Multiome | 901 | |
| chr1:156,673,575–156,674,145 | 93.7 kb | Distal (>10kb) Multiome | 269 | |
| chr1:156,676,488–156,677,779 | 90.2 kb | Distal (>10kb) Multiome | 449 | |
| chr1:156,689,084–156,690,144 | 77.9 kb | Distal (>10kb) Multiome | 508 | |
| chr1:156,692,653–156,693,825 | 74.4 kb | Distal (>10kb) Multiome | 493 | |
| chr1:156,703,427–156,704,626 | 63.6 kb | Distal (>10kb) Multiome | 182 | |
| chr1:156,704,839–156,707,238 | 61.4 kb | Distal (>10kb) Multiome | 728 | |
| chr1:156,708,331–156,708,813 | 59.1 kb | Distal (>10kb) Multiome | 108 | |
| chr1:156,728,152–156,729,282 | 38.8 kb | Distal (>10kb) Multiome | 815 | |
| chr1:156,740,482–156,741,987 | 26.3 kb | Distal (>10kb) Multiome | 1012 | |
| chr1:156,746,390–156,748,386 | 20.3 kb | Distal (>10kb) Multiome | 750 | |
| chr1:156,751,012–156,752,594 | 15.7 kb | Distal (>10kb) Multiome | 869 | |
| chr1:156,766,695–156,768,280 | 162 bp | At TSS Multiome | 967 | |
| chr1:156,813,606–156,814,470 | 46.5 kb | Distal (>10kb) Multiome | 756 | |
| chr1:156,845,268–156,845,794 | 78.0 kb | Distal (>10kb) Multiome | 73 | |
| chr1:156,848,614–156,849,138 | 81.4 kb | Distal (>10kb) Multiome | 129 | |
| chr1:156,860,147–156,861,294 | 93.1 kb | Distal (>10kb) Multiome | 484 | |
| chr1:156,862,753–156,863,585 | 95.7 kb | Distal (>10kb) Multiome | 268 | |
| chr1:156,892,162–156,892,597 | 124.9 kb | Distal (>10kb) Multiome | 439 | |
| chr1:156,893,409–156,893,975 | 126.3 kb | Distal (>10kb) Multiome | 143 | |
| chr1:156,920,128–156,921,047 | 153.0 kb | Distal (>10kb) Multiome | 508 | |
| chr1:156,927,257–156,928,255 | 160.3 kb | Distal (>10kb) Multiome | 424 | |
| chr1:156,996,881–156,997,694 | 229.8 kb | Distal (>10kb) Multiome | 167 | |
| chr1:157,045,268–157,046,656 | 278.4 kb | Distal (>10kb) Multiome | 678 |
Genomic view of the PRCC locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.