The protein encoded by this gene is similar to PPAR-gamma coactivator 1 (PPARGC1/PGC-1), a protein that can activate mitochondrial biogenesis in part through a direct interaction with nuclear respiratory factor 1 (NRF1). This protein has been shown to interact with NRF1. It is thought to be a functional relative of PPAR-gamma coactivator 1 that activates mitochondrial biogenesis through NRF1 in response to proliferative signals. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Transcription factors with Perturb-seq knockdown data for PPRC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPRC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPRC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:101,839,408–101,839,998 | 293.4 kb | Distal (>10kb) Multiome | 196 | |
| chr10:101,840,663–101,841,471 | 292.0 kb | Distal (>10kb) Multiome | 499 | |
| chr10:101,843,178–101,844,328 | 289.3 kb | Distal (>10kb) Multiome | 277 | |
| chr10:101,893,696–101,895,001 | 238.5 kb | Distal (>10kb) Multiome | 142 | |
| chr10:101,960,808–101,961,342 | 171.9 kb | Distal (>10kb) Multiome | 47 | |
| chr10:102,055,474–102,056,435 | 76.9 kb | Distal (>10kb) Multiome | 955 | |
| chr10:102,064,619–102,066,067 | 67.7 kb | Distal (>10kb) Multiome | 778 | |
| chr10:102,114,483–102,115,579 | 18.0 kb | Distal (>10kb) Multiome | 546 | |
| chr10:102,119,389–102,122,276 | 12.5 kb | Distal (>10kb) Multiome | 934 | |
| chr10:102,132,334–102,133,845 | 120 bp | At TSS Multiome | 968 | |
| chr10:102,151,480–102,152,882 | 19.2 kb | Distal (>10kb) Multiome | 1009 | |
| chr10:102,169,504–102,169,976 | 36.6 kb | Distal (>10kb) Multiome | 398 | |
| chr10:102,225,881–102,226,551 | 93.2 kb | Distal (>10kb) Multiome | 652 | |
| chr10:102,229,814–102,232,116 | 96.9 kb | Distal (>10kb) Multiome | 689 | |
| chr10:102,240,581–102,242,031 | 108.6 kb | Distal (>10kb) Multiome | 504 | |
| chr10:102,244,918–102,246,010 | 112.4 kb | Distal (>10kb) Multiome | 734 | |
| chr10:102,393,940–102,396,107 | 262.7 kb | Distal (>10kb) Multiome | 912 | |
| chr10:102,399,132–102,400,002 | 266.6 kb | Distal (>10kb) Multiome | 832 | |
| chr10:102,408,600–102,409,538 | 276.0 kb | Distal (>10kb) Multiome | 277 | |
| chr10:102,410,213–102,410,909 | 277.7 kb | Distal (>10kb) Multiome | 148 | |
| chr10:102,418,158–102,422,381 | 286.6 kb | Distal (>10kb) Multiome | 1097 | |
| chr10:102,422,562–102,423,126 | 289.9 kb | Distal (>10kb) Multiome | 721 | |
| chr10:102,431,859–102,432,863 | 299.6 kb | Distal (>10kb) Multiome | 828 |
Genomic view of the PPRC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.