The protein encoded by this gene is a regulatory protein for the protein phosphatase-6 catalytic subunit. Together, these proteins act as a significant T-loop phosphatase for Aurora A, an essential mitotic kinase. Loss of function of either the regulatory or catalytic subunit of protein phosphatase-6 interferes with spindle formation and chromosome alignment. [provided by RefSeq, May 2017]
Transcription factors with Perturb-seq knockdown data for PPP6R2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPP6R2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPP6R2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:50,169,918–50,170,446 | 173.1 kb | Distal (>10kb) Multiome | 245 | |
| chr22:50,184,288–50,186,776 | 157.5 kb | Distal (>10kb) Multiome | 542 | |
| chr22:50,199,706–50,201,679 | 142.3 kb | Distal (>10kb) Multiome | 612 | |
| chr22:50,244,340–50,245,635 | 98.3 kb | Distal (>10kb) Multiome | 868 | |
| chr22:50,250,480–50,251,917 | 92.0 kb | Distal (>10kb) Multiome | 683 | |
| chr22:50,261,070–50,261,932 | 81.7 kb | Distal (>10kb) Multiome | 512 | |
| chr22:50,267,469–50,268,208 | 75.6 kb | Distal (>10kb) Multiome | 196 | |
| chr22:50,271,717–50,272,193 | 71.4 kb | Distal (>10kb) Multiome | 331 | |
| chr22:50,299,702–50,300,750 | 42.9 kb | Distal (>10kb) Multiome | 250 | |
| chr22:50,307,140–50,307,760 | 35.7 kb | Distal (>10kb) Multiome | 392 | |
| chr22:50,326,615–50,327,631 | 16.2 kb | Distal (>10kb) Multiome | 754 | |
| chr22:50,342,153–50,342,608 | 829 bp | At TSS Multiome | 553 | |
| chr22:50,342,772–50,343,603 | 125 bp | At TSS Multiome | 573 | |
| chr22:50,474,348–50,475,571 | 131.8 kb | Distal (>10kb) Multiome | 487 | |
| chr22:50,481,062–50,482,150 | 138.2 kb | Distal (>10kb) Multiome | 387 | |
| chr22:50,506,343–50,508,710 | 164.7 kb | Distal (>10kb) Multiome | 856 | |
| chr22:50,524,965–50,527,480 | 183.8 kb | Distal (>10kb) Multiome | 1031 | |
| chr22:50,529,065–50,532,692 | 187.6 kb | Distal (>10kb) Multiome | 745 | |
| chr22:50,562,609–50,563,508 | 219.6 kb | Distal (>10kb) Multiome | 680 | |
| chr22:50,582,134–50,583,431 | 239.6 kb | Distal (>10kb) Multiome | 871 | |
| chr22:50,627,527–50,628,705 | 284.9 kb | Distal (>10kb) Multiome | 685 |
Genomic view of the PPP6R2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.