PPP6R1

protein phosphatase 6 regulatory subunit 1 | SAP190, KIAA1115, SAPS1

Protein phosphatase regulatory subunits, such as SAPS1, modulate the activity of protein phosphatase catalytic subunits by restricting substrate specificity, recruiting substrates, and determining the intracellular localization of the holoenzyme. SAPS1 is a regulatory subunit for the protein phosphatase-6 catalytic subunit (PPP6C; MIM 612725) (Stefansson and Brautigan, 2006 [PubMed 16769727]).[supplied by OMIM, Nov 2010]

Member of: DE-6 Developmental clusters: GC1

Biological processes 12 terms

cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)lamellipodium (GO:0030027)nucleus (GO:0005634)protein binding (GO:0005515)protein phosphatase binding (GO:0019903)protein phosphatase regulator activity (GO:0019888)protein phosphatase regulator activity (GO:0019888)regulation of signal transduction (GO:0009966)small GTPase binding (GO:0031267)

Expression (TPM)

TFs regulating PPP6R1 0 TFs

Transcription factors with Perturb-seq knockdown data for PPP6R1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPP6R1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to PPP6R1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPP6R1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:55,062,536–55,063,406	195.8 kb	Distal (>10kb) Multiome	586
chr19:55,069,129–55,069,807	189.6 kb	Distal (>10kb) Multiome	288
chr19:55,080,038–55,082,744	177.5 kb	Distal (>10kb) Multiome	639
chr19:55,086,246–55,087,525	171.9 kb	Distal (>10kb) Multiome	258
chr19:55,091,780–55,093,292	166.7 kb	Distal (>10kb) Multiome	208
chr19:55,095,398–55,095,977	163.2 kb	Distal (>10kb) Multiome	90
chr19:55,117,134–55,119,109	141.3 kb	Distal (>10kb) Multiome	881
chr19:55,146,210–55,148,117	112.1 kb	Distal (>10kb) Multiome	528
chr19:55,156,193–55,157,266	102.4 kb	Distal (>10kb) Multiome	317
chr19:55,160,567–55,161,360	98.3 kb	Distal (>10kb) Multiome	554
chr19:55,165,952–55,167,256	92.3 kb	Distal (>10kb) Multiome	719
chr19:55,173,717–55,174,287	84.9 kb	Distal (>10kb) Multiome	330
chr19:55,178,876–55,179,477	79.9 kb	Distal (>10kb) Multiome	479
chr19:55,216,490–55,217,227	42.1 kb	Distal (>10kb) Multiome	1077
chr19:55,257,751–55,259,635	183 bp	At TSS Multiome	1054
chr19:55,279,599–55,280,933	21.3 kb	Distal (>10kb) Multiome	805
chr19:55,283,835–55,284,716	25.0 kb	Distal (>10kb) Multiome	242
chr19:55,301,640–55,302,240	42.9 kb	Distal (>10kb) Multiome	448
chr19:55,338,676–55,340,358	80.6 kb	Distal (>10kb) Multiome	882
chr19:55,340,675–55,341,535	82.4 kb	Distal (>10kb) Multiome	368
chr19:55,353,720–55,354,487	95.1 kb	Distal (>10kb) Multiome	297
chr19:55,369,099–55,370,447	111.0 kb	Distal (>10kb) Multiome	383
chr19:55,383,539–55,384,553	124.9 kb	Distal (>10kb) Multiome	374
chr19:55,384,697–55,386,560	126.7 kb	Distal (>10kb) Multiome	903
chr19:55,406,950–55,408,675	149.0 kb	Distal (>10kb) Multiome	965
chr19:55,452,738–55,453,308	194.1 kb	Distal (>10kb) Multiome	339
chr19:55,460,784–55,462,230	202.8 kb	Distal (>10kb) Multiome	947
chr19:55,476,048–55,477,307	217.7 kb	Distal (>10kb) Multiome	1007
chr19:55,484,846–55,485,682	226.2 kb	Distal (>10kb) Multiome	594
chr19:55,503,638–55,504,310	245.0 kb	Distal (>10kb) Multiome	710
chr19:55,516,768–55,517,459	258.1 kb	Distal (>10kb) Multiome	583
chr19:55,536,923–55,537,366	278.2 kb	Distal (>10kb) Multiome	180
chr19:55,549,822–55,550,343	291.1 kb	Distal (>10kb) Multiome	396

Genome Browser

Genomic view of the PPP6R1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.