PPP5C
protein phosphatase 5 catalytic subunit | PP5, PPP5

This gene encodes a serine/threonine phosphatase which is a member of the protein phosphatase catalytic subunit family. Proteins in this family participate in pathways regulated by reversible phosphorylation at serine and threonine residues; many of these pathways are involved in the regulation of cell growth and differentiation. The product of this gene has been shown to participate in signaling pathways in response to hormones or cellular stress, and elevated levels of this protein may be associated with breast cancer development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2011]

Member of: DE-6
Biological processes 55 terms
ADP binding (GO:0043531)ATP binding (GO:0005524)DNA-templated transcription (GO:0006351)G-protein alpha-subunit binding (GO:0001965)Hsp70 protein binding (GO:0030544)Hsp90 protein binding (GO:0051879)Hsp90 protein binding (GO:0051879)MAPK cascade (GO:0000165)RNA binding (GO:0003723)cellular response to cadmium ion (GO:0071276)cellular response to hydrogen peroxide (GO:0070301)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)double-strand break repair (GO:0006302)heat shock protein binding (GO:0031072)hydrolase activity (GO:0016787)identical protein binding (GO:0042802)microtubule binding (GO:0008017)mitogen-activated protein kinase kinase kinase binding (GO:0031435)mitotic cell cycle (GO:0000278)negative regulation of MAPK cascade (GO:0043409)negative regulation of apoptotic process (GO:0043066)neuronal cell body (GO:0043025)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)peptidyl-serine dephosphorylation (GO:0070262)perikaryon (GO:0043204)phosphatase activity (GO:0016791)phosphoprotein phosphatase activity (GO:0004721)phosphoprotein phosphatase activity (GO:0004721)phosphoprotein phosphatase activity (GO:0004721)plasma membrane (GO:0005886)positive regulation of canonical NF-kappaB signal transduction (GO:0043123)positive regulation of nuclear receptor-mediated glucocorticoid signaling pathway (GO:2000324)protein binding (GO:0005515)protein folding chaperone complex (GO:0101031)protein serine/threonine kinase inhibitor activity (GO:0030291)protein serine/threonine phosphatase activity (GO:0004722)protein serine/threonine phosphatase activity (GO:0004722)protein serine/threonine phosphatase activity (GO:0004722)protein serine/threonine phosphatase activity (GO:0004722)protein serine/threonine phosphatase activity (GO:0004722)protein-containing complex (GO:0032991)protein-containing complex binding (GO:0044877)proximal dendrite (GO:1990635)response to arachidonate (GO:1904550)response to arachidonate (GO:1904550)response to lead ion (GO:0010288)response to lead ion (GO:0010288)tau protein binding (GO:0048156)
Expression (TPM)
PPP5C — as a Regulated Gene

TFs regulating PPP5C 0 TFs

Transcription factors with Perturb-seq knockdown data for PPP5C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPP5C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to PPP5C

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPP5C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr19:46,076,819–46,077,882 269.5 kb Distal (>10kb) Multiome 516
chr19:46,133,049–46,133,620 213.6 kb Distal (>10kb) Multiome 189
chr19:46,186,238–46,186,877 160.5 kb Distal (>10kb) Multiome 83
chr19:46,240,361–46,242,067 106.3 kb Distal (>10kb) Multiome 199
chr19:46,264,949–46,266,023 81.6 kb Distal (>10kb) Multiome 189
chr19:46,270,338–46,270,840 76.4 kb Distal (>10kb) Multiome 63
chr19:46,278,494–46,279,057 68.5 kb Distal (>10kb) Multiome 15
chr19:46,296,572–46,297,359 50.1 kb Distal (>10kb) Multiome 158
chr19:46,300,632–46,301,183 46.1 kb Distal (>10kb) Multiome 282
chr19:46,303,439–46,304,504 42.9 kb Distal (>10kb) Multiome 300
chr19:46,346,454–46,347,599 10 bp At TSS Multiome 835
chr19:46,373,466–46,374,149 26.7 kb Distal (>10kb) Multiome 293
chr19:46,413,092–46,414,029 66.5 kb Distal (>10kb) Multiome 530
chr19:46,416,168–46,416,925 69.5 kb Distal (>10kb) Multiome 522
chr19:46,426,339–46,427,101 79.7 kb Distal (>10kb) Multiome 220
chr19:46,471,149–46,471,898 124.4 kb Distal (>10kb) Multiome 339
chr19:46,495,489–46,496,206 148.8 kb Distal (>10kb) Multiome 177
chr19:46,587,845–46,588,467 241.0 kb Distal (>10kb) Multiome 21
chr19:46,600,411–46,601,577 253.9 kb Distal (>10kb) Multiome 1006
chr19:46,633,826–46,635,061 287.3 kb Distal (>10kb) Multiome 365
chr19:46,638,437–46,639,929 291.9 kb Distal (>10kb) Multiome 741

Genome Browser

Genomic view of the PPP5C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr19:46,066,819 – 46,649,929
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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