The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a delta isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PPP2R5D. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPP2R5D upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPP2R5D, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:42,710,310–42,710,904 | 274.1 kb | Distal (>10kb) Multiome | 100 | |
| chr6:42,745,261–42,747,361 | 238.4 kb | Distal (>10kb) Multiome | 1101 | |
| chr6:42,770,933–42,771,516 | 213.4 kb | Distal (>10kb) Multiome | 283 | |
| chr6:42,782,323–42,783,894 | 201.6 kb | Distal (>10kb) Multiome | 960 | |
| chr6:42,879,371–42,880,327 | 104.8 kb | Distal (>10kb) Multiome | 982 | |
| chr6:42,890,329–42,891,383 | 93.8 kb | Distal (>10kb) Multiome | 1066 | |
| chr6:42,911,181–42,912,079 | 72.9 kb | Distal (>10kb) Multiome | 327 | |
| chr6:42,928,809–42,930,153 | 55.2 kb | Distal (>10kb) Multiome | 1111 | |
| chr6:42,960,347–42,961,147 | 23.9 kb | Distal (>10kb) Multiome | 597 | |
| chr6:42,978,475–42,979,742 | 5.4 kb | Proximal (<10kb) Multiome | 914 | |
| chr6:42,983,832–42,985,046 | 152 bp | At TSS Multiome | 737 | |
| chr6:43,013,264–43,014,790 | 29.5 kb | Distal (>10kb) Multiome | 874 | |
| chr6:43,020,970–43,021,878 | 36.9 kb | Distal (>10kb) Multiome | 766 | |
| chr6:43,053,156–43,054,116 | 69.3 kb | Distal (>10kb) Multiome | 1033 | |
| chr6:43,059,118–43,060,383 | 75.0 kb | Distal (>10kb) Multiome | 906 | |
| chr6:43,075,612–43,077,611 | 92.8 kb | Distal (>10kb) Multiome | 744 | |
| chr6:43,096,382–43,096,822 | 111.9 kb | Distal (>10kb) Multiome | 290 | |
| chr6:43,143,296–43,143,802 | 159.0 kb | Distal (>10kb) Multiome | 638 | |
| chr6:43,170,289–43,172,815 | 186.6 kb | Distal (>10kb) Multiome | 1025 | |
| chr6:43,173,720–43,174,910 | 190.0 kb | Distal (>10kb) Multiome | 765 | |
| chr6:43,181,838–43,182,555 | 197.6 kb | Distal (>10kb) Multiome | 874 | |
| chr6:43,228,982–43,229,794 | 244.8 kb | Distal (>10kb) Multiome | 918 | |
| chr6:43,246,576–43,247,616 | 262.6 kb | Distal (>10kb) Multiome | 750 | |
| chr6:43,267,244–43,268,167 | 283.1 kb | Distal (>10kb) Multiome | 772 |
Genomic view of the PPP2R5D locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.