Predicted to enable enzyme-substrate adaptor activity and protein phosphatase regulator activity. Predicted to be involved in exit from mitosis and regulation of chromosome segregation. Predicted to be located in cytoplasm. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PPP2R2D. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPP2R2D upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPP2R2D, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:131,676,753–131,677,316 | 223.9 kb | Distal (>10kb) Multiome | 131 | |
| chr10:131,874,962–131,875,578 | 25.8 kb | Distal (>10kb) Multiome | 227 | |
| chr10:131,899,878–131,901,850 | 291 bp | At TSS Multiome | 732 | |
| chr10:131,929,125–131,929,784 | 28.4 kb | Distal (>10kb) Multiome | 62 | |
| chr10:131,981,341–131,982,864 | 81.1 kb | Distal (>10kb) Multiome | 815 | |
| chr10:131,998,677–131,999,655 | 98.2 kb | Distal (>10kb) Multiome | 271 | |
| chr10:132,001,275–132,002,395 | 100.7 kb | Distal (>10kb) Multiome | 161 | |
| chr10:132,002,510–132,004,411 | 102.5 kb | Distal (>10kb) Multiome | 240 | |
| chr10:132,035,668–132,037,081 | 135.6 kb | Distal (>10kb) Multiome | 214 | |
| chr10:132,112,772–132,114,093 | 212.3 kb | Distal (>10kb) Multiome | 141 | |
| chr10:132,163,327–132,163,783 | 262.6 kb | Distal (>10kb) Multiome | 240 | |
| chr10:132,185,497–132,188,136 | 284.7 kb | Distal (>10kb) Multiome | 418 |
Genomic view of the PPP2R2D locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.