This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes a beta isoform of the catalytic subunit. [provided by RefSeq, Mar 2010]
Transcription factors with Perturb-seq knockdown data for PPP2CB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPP2CB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPP2CB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:30,541,211–30,542,932 | 271.1 kb | Distal (>10kb) Multiome | 253 | |
| chr8:30,555,639–30,556,644 | 256.8 kb | Distal (>10kb) Multiome | 396 | |
| chr8:30,657,598–30,658,716 | 154.6 kb | Distal (>10kb) Multiome | 834 | |
| chr8:30,727,108–30,728,427 | 84.9 kb | Distal (>10kb) Multiome | 986 | |
| chr8:30,743,665–30,744,537 | 68.6 kb | Distal (>10kb) Multiome | 789 | |
| chr8:30,811,955–30,813,256 | 47 bp | At TSS Multiome | 824 | |
| chr8:30,817,124–30,817,779 | 4.6 kb | Proximal (<10kb) Multiome | 166 | |
| chr8:30,911,618–30,912,683 | 99.3 kb | Distal (>10kb) Multiome | 460 | |
| chr8:31,032,234–31,034,302 | 220.9 kb | Distal (>10kb) Multiome | 723 |
Genomic view of the PPP2CB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.