PPP2CA

protein phosphatase 2 catalytic subunit alpha | PP2AC, PP2Calpha

This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit. [provided by RefSeq, Jul 2008]

Member of: DE-1 DE-1.28

Biological processes 71 terms

FAR/SIN/STRIPAK complex (GO:0090443)FAR/SIN/STRIPAK complex (GO:0090443)GABA receptor binding (GO:0050811)INTAC complex (GO:0160232)RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity (GO:0180006)RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity (GO:0180007)RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity (GO:0180008)RNA polymerase II transcription initiation surveillance (GO:0160240)T cell homeostasis (GO:0043029)T cell homeostasis (GO:0043029)chromatin (GO:0000785)chromosome (GO:0005694)chromosome, centromeric region (GO:0000775)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)extracellular exosome (GO:0070062)hydrolase activity (GO:0016787)intracellular signal transduction (GO:0035556)membrane (GO:0016020)membrane raft (GO:0045121)microtubule cytoskeleton (GO:0015630)mitochondrion (GO:0005739)mitotic cell cycle (GO:0000278)negative regulation of canonical Wnt signaling pathway (GO:0090090)negative regulation of epithelial to mesenchymal transition (GO:0010719)negative regulation of glycolytic process through fructose-6-phosphate (GO:1904539)negative regulation of hippo signaling (GO:0035331)negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (GO:0051898)negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (GO:0051898)negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (GO:0051898)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)phosphoprotein phosphatase activity (GO:0004721)phosphoprotein phosphatase activity (GO:0004721)plasma membrane (GO:0005886)positive regulation of NLRP3 inflammasome complex assembly (GO:1900227)positive regulation of NLRP3 inflammasome complex assembly (GO:1900227)protein binding (GO:0005515)protein dephosphorylation (GO:0006470)protein dephosphorylation (GO:0006470)protein heterodimerization activity (GO:0046982)protein phosphatase type 2A complex (GO:0000159)protein phosphatase type 2A complex (GO:0000159)protein phosphatase type 2A complex (GO:0000159)protein serine/threonine phosphatase activity (GO:0004722)protein serine/threonine phosphatase activity (GO:0004722)protein serine/threonine phosphatase activity (GO:0004722)protein serine/threonine phosphatase activity (GO:0004722)protein serine/threonine phosphatase activity (GO:0004722)protein serine/threonine phosphatase activity (GO:0004722)protein serine/threonine phosphatase complex (GO:0008287)protein tyrosine phosphatase activity (GO:0004725)regulation of G1/S transition of mitotic cell cycle (GO:2000045)regulation of cell differentiation (GO:0045595)regulation of growth (GO:0040008)regulation of hippo signaling (GO:0035330)regulation of microtubule polymerization (GO:0031113)regulation of transcription by RNA polymerase II (GO:0006357)regulation of transcription elongation by RNA polymerase II (GO:0034243)response to lead ion (GO:0010288)response to lead ion (GO:0010288)snRNA processing (GO:0016180)spindle pole (GO:0000922)synapse (GO:0045202)tau protein binding (GO:0048156)vascular endothelial cell response to oscillatory fluid shear stress (GO:0097706)

Expression (TPM)

TFs regulating PPP2CA 0 TFs

Transcription factors with Perturb-seq knockdown data for PPP2CA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPP2CA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to PPP2CA

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPP2CA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr5:133,968,103–133,968,907	257.4 kb	Distal (>10kb) Multiome	861
chr5:134,004,027–134,006,483	221.2 kb	Distal (>10kb) Multiome	948
chr5:134,039,553–134,040,013	186.3 kb	Distal (>10kb) Multiome	576
chr5:134,070,573–134,071,963	154.8 kb	Distal (>10kb) Multiome	666
chr5:134,099,891–134,100,749	125.9 kb	Distal (>10kb) Multiome	227
chr5:134,101,617–134,102,291	124.0 kb	Distal (>10kb) Multiome	334
chr5:134,113,043–134,116,112	110.4 kb	Distal (>10kb) Multiome	637
chr5:134,140,528–134,140,995	85.3 kb	Distal (>10kb) Multiome	342
chr5:134,176,142–134,177,562	49.1 kb	Distal (>10kb) Multiome	952
chr5:134,184,086–134,184,650	41.7 kb	Distal (>10kb) Multiome	289
chr5:134,225,248–134,227,248	185 bp	At TSS Multiome	1043
chr5:134,227,365–134,227,538	1.3 kb	Proximal (<10kb)	103
chr5:134,366,722–134,367,362	141.1 kb	Distal (>10kb) Multiome	682
chr5:134,370,722–134,372,303	145.2 kb	Distal (>10kb) Multiome	1080
chr5:134,411,465–134,412,433	185.9 kb	Distal (>10kb) Multiome	989
chr5:134,465,626–134,467,213	239.9 kb	Distal (>10kb) Multiome	926
chr5:134,506,114–134,506,990	280.3 kb	Distal (>10kb) Multiome	644
chr5:134,511,761–134,512,800	286.2 kb	Distal (>10kb) Multiome	505
chr5:134,523,964–134,528,361	298.4 kb	Distal (>10kb) Multiome	1077

Genome Browser

Genomic view of the PPP2CA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.