PPP1R3B

protein phosphatase 1 regulatory subunit 3B | FLJ14005, GL, PPP1R4

This gene encodes the catalytic subunit of the serine/theonine phosphatase, protein phosphatase-1. The encoded protein is expressed in liver and skeletal muscle tissue and may be involved in regulating glycogen synthesis in these tissues. This gene may be a involved in type 2 diabetes and maturity-onset diabetes of the young. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, Jan 2011]

Member of: DE-4 DE-4.10 Developmental clusters: GC2 GC2

Biological processes 15 terms

[phosphorylase] phosphatase activity (GO:0050196)enzyme binding (GO:0019899)glycogen binding (GO:2001069)glycogen granule (GO:0042587)negative regulation of glycogen catabolic process (GO:0045818)phosphoprotein phosphatase activity (GO:0004721)positive regulation of glycogen biosynthetic process (GO:0045725)protein binding (GO:0005515)protein phosphatase 1 binding (GO:0008157)protein phosphatase regulator activity (GO:0019888)protein phosphatase type 1 complex (GO:0000164)protein phosphatase type 1 complex (GO:0000164)regulation of glycogen biosynthetic process (GO:0005979)regulation of glycogen biosynthetic process (GO:0005979)regulation of glycogen catabolic process (GO:0005981)

Expression (TPM)

TFs regulating PPP1R3B 0 TFs

Transcription factors with Perturb-seq knockdown data for PPP1R3B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPP1R3B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to PPP1R3B

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPP1R3B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr8:8,891,982–8,894,021	257.1 kb	Distal (>10kb) Multiome	613
chr8:8,963,219–8,963,764	187.2 kb	Distal (>10kb) Multiome	278
chr8:9,002,478–9,003,402	147.8 kb	Distal (>10kb) Multiome	894
chr8:9,057,454–9,058,557	92.5 kb	Distal (>10kb) Multiome	293
chr8:9,101,993–9,102,949	48.2 kb	Distal (>10kb) Multiome	546
chr8:9,123,903–9,124,447	26.4 kb	Distal (>10kb) Multiome	32
chr8:9,150,157–9,151,970	91 bp	At TSS Multiome	725
chr8:9,183,123–9,184,864	33.0 kb	Distal (>10kb) Multiome	265
chr8:9,263,600–9,264,957	113.8 kb	Distal (>10kb) Multiome	114
chr8:9,296,640–9,298,063	146.5 kb	Distal (>10kb) Multiome	163
chr8:9,412,347–9,413,021	261.9 kb	Distal (>10kb) Multiome	227

Genome Browser

Genomic view of the PPP1R3B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.