Predicted to enable protein serine/threonine phosphatase inhibitor activity. Predicted to be involved in intracellular signal transduction. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PPP1R1A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPP1R1A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPP1R1A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:54,300,732–54,301,299 | 287.5 kb | Distal (>10kb) Multiome | 545 | |
| chr12:54,324,486–54,325,464 | 263.7 kb | Distal (>10kb) Multiome | 885 | |
| chr12:54,358,730–54,359,779 | 229.4 kb | Distal (>10kb) Multiome | 857 | |
| chr12:54,370,156–54,370,782 | 218.2 kb | Distal (>10kb) Multiome | 399 | |
| chr12:54,378,747–54,380,140 | 209.5 kb | Distal (>10kb) Multiome | 649 | |
| chr12:54,390,265–54,391,699 | 197.3 kb | Distal (>10kb) Multiome | 393 | |
| chr12:54,419,123–54,419,837 | 169.4 kb | Distal (>10kb) Multiome | 441 | |
| chr12:54,549,254–54,550,339 | 39.0 kb | Distal (>10kb) Multiome | 365 | |
| chr12:54,579,588–54,580,234 | 8.7 kb | Proximal (<10kb) Multiome | 271 | |
| chr12:54,588,122–54,588,928 | 75 bp | At TSS Multiome | 182 | |
| chr12:54,596,504–54,596,918 | 7.8 kb | Proximal (<10kb) | 178 | |
| chr12:54,683,314–54,683,885 | 95.0 kb | Distal (>10kb) Multiome | 164 |
Genomic view of the PPP1R1A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.