PPP1R13L

protein phosphatase 1 regulatory subunit 13 like | IASPP, RAI

IASPP is one of the most evolutionarily conserved inhibitors of p53 (TP53; MIM 191170), whereas ASPP1 (MIM 606455) and ASPP2 (MIM 602143) are activators of p53.[supplied by OMIM, Mar 2008]

Member of: DE-4 Developmental clusters: GC6

Biological processes 16 terms

cadherin binding (GO:0045296)cytoplasm (GO:0005737)cytosol (GO:0005829)identical protein binding (GO:0042802)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of inflammatory response (GO:0050728)negative regulation of inflammatory response (GO:0050728)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of cell differentiation (GO:0045597)positive regulation of cell differentiation (GO:0045597)protein binding (GO:0005515)regulation of DNA-templated transcription (GO:0006355)regulation of transcription by RNA polymerase II (GO:0006357)transcription corepressor activity (GO:0003714)

Expression (TPM)

TFs regulating PPP1R13L 0 TFs

Transcription factors with Perturb-seq knockdown data for PPP1R13L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPP1R13L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to PPP1R13L

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPP1R13L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:45,177,803–45,179,711	227.8 kb	Distal (>10kb) Multiome	899
chr19:45,234,200–45,234,822	171.8 kb	Distal (>10kb) Multiome	105
chr19:45,250,821–45,251,491	155.1 kb	Distal (>10kb) Multiome	397
chr19:45,340,431–45,341,201	65.5 kb	Distal (>10kb) Multiome	363
chr19:45,370,064–45,371,122	35.7 kb	Distal (>10kb) Multiome	592
chr19:45,398,068–45,398,489	6.6 kb	Proximal (<10kb)	281
chr19:45,402,280–45,402,828	3.8 kb	Proximal (<10kb) Multiome	332
chr19:45,403,781–45,404,684	2.3 kb	Proximal (<10kb) Multiome	494
chr19:45,404,818–45,406,887	175 bp	At TSS Multiome	964
chr19:45,423,326–45,424,545	17.4 kb	Distal (>10kb) Multiome	996
chr19:45,439,539–45,440,189	33.5 kb	Distal (>10kb) Multiome	718
chr19:45,443,052–45,444,768	37.2 kb	Distal (>10kb) Multiome	857
chr19:45,450,695–45,451,265	44.5 kb	Distal (>10kb) Multiome	515
chr19:45,455,706–45,456,201	49.6 kb	Distal (>10kb) Multiome	776
chr19:45,467,169–45,468,696	61.4 kb	Distal (>10kb) Multiome	686
chr19:45,468,843–45,470,312	63.1 kb	Distal (>10kb) Multiome	769
chr19:45,478,416–45,479,276	72.5 kb	Distal (>10kb) Multiome	809
chr19:45,485,144–45,486,070	79.2 kb	Distal (>10kb) Multiome HiCAR	659
chr19:45,492,647–45,493,344	86.6 kb	Distal (>10kb) Multiome	522
chr19:45,496,247–45,497,677	90.7 kb	Distal (>10kb) Multiome	742
chr19:45,498,270–45,499,916	93.2 kb	Distal (>10kb) Multiome	464
chr19:45,506,243–45,507,963	100.4 kb	Distal (>10kb) Multiome	969
chr19:45,508,291–45,509,751	102.3 kb	Distal (>10kb) Multiome	670
chr19:45,528,315–45,529,353	122.5 kb	Distal (>10kb) Multiome	425
chr19:45,584,026–45,585,251	178.3 kb	Distal (>10kb) Multiome	907
chr19:45,607,096–45,607,695	201.1 kb	Distal (>10kb) Multiome	526
chr19:45,615,654–45,616,944	209.8 kb	Distal (>10kb) Multiome	480
chr19:45,632,406–45,633,148	226.4 kb	Distal (>10kb) Multiome	358
chr19:45,638,965–45,639,696	233.0 kb	Distal (>10kb) Multiome	477
chr19:45,640,813–45,642,557	236.0 kb	Distal (>10kb) Multiome	865
chr19:45,643,187–45,644,012	237.3 kb	Distal (>10kb) Multiome	542
chr19:45,645,389–45,646,343	239.6 kb	Distal (>10kb) Multiome	566
chr19:45,667,856–45,668,417	261.7 kb	Distal (>10kb) Multiome	386
chr19:45,668,914–45,669,719	263.0 kb	Distal (>10kb) Multiome	611
chr19:45,670,481–45,671,446	264.7 kb	Distal (>10kb) Multiome	361
chr19:45,676,875–45,678,209	271.2 kb	Distal (>10kb) Multiome	418
chr19:45,681,530–45,682,004	275.4 kb	Distal (>10kb) Multiome	648
chr19:45,691,622–45,693,062	286.1 kb	Distal (>10kb) Multiome	943

Genome Browser

Genomic view of the PPP1R13L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.