The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PPM1D. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPM1D upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPM1D, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:60,327,303–60,327,917 | 272.5 kb | Distal (>10kb) Multiome | 115 | |
| chr17:60,384,860–60,385,543 | 215.0 kb | Distal (>10kb) Multiome | 76 | |
| chr17:60,391,203–60,392,936 | 207.9 kb | Distal (>10kb) Multiome | 1085 | |
| chr17:60,421,283–60,422,169 | 178.6 kb | Distal (>10kb) Multiome | 479 | |
| chr17:60,525,577–60,526,500 | 74.0 kb | Distal (>10kb) Multiome | 955 | |
| chr17:60,579,473–60,580,626 | 20.3 kb | Distal (>10kb) Multiome | 205 | |
| chr17:60,592,684–60,592,851 | 7.3 kb | Proximal (<10kb) | 19 | |
| chr17:60,599,336–60,601,434 | 64 bp | At TSS Multiome | 1120 | |
| chr17:60,602,052–60,602,208 | 1.9 kb | Proximal (<10kb) | 303 | |
| chr17:60,676,921–60,678,448 | 77.5 kb | Distal (>10kb) Multiome | 986 |
Genomic view of the PPM1D locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.