The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein has been shown to possess PPIase activity and, similar to other family members, can bind to the immunosuppressant cyclosporin A. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PPID. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPID upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPID, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:158,571,551–158,572,520 | 151.4 kb | Distal (>10kb) Multiome | 128 | |
| chr4:158,670,728–158,672,956 | 52.5 kb | Distal (>10kb) Multiome | 1090 | |
| chr4:158,722,296–158,722,696 | 699 bp | At TSS | 229 | |
| chr4:158,722,797–158,723,912 | 24 bp | At TSS Multiome | 859 | |
| chr4:158,730,041–158,730,260 | 6.6 kb | Proximal (<10kb) | 251 | |
| chr4:158,768,346–158,769,735 | 45.5 kb | Distal (>10kb) Multiome | 747 | |
| chr4:158,782,620–158,783,783 | 59.6 kb | Distal (>10kb) Multiome | 413 | |
| chr4:158,902,258–158,903,267 | 179.4 kb | Distal (>10kb) Multiome | 354 |
Genomic view of the PPID locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.