Predicted to be involved in cell differentiation. Predicted to act upstream of or within TORC1 signaling and liver development. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PPDPF. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPDPF upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPDPF, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:63,272,274–63,273,137 | 248.0 kb | Distal (>10kb) Multiome | 736 | |
| chr20:63,409,631–63,410,124 | 110.9 kb | Distal (>10kb) Multiome | 60 | |
| chr20:63,471,533–63,472,788 | 48.1 kb | Distal (>10kb) Multiome | 219 | |
| chr20:63,488,166–63,488,632 | 32.3 kb | Distal (>10kb) Multiome | 127 | |
| chr20:63,498,850–63,499,391 | 21.5 kb | Distal (>10kb) Multiome | 232 | |
| chr20:63,519,657–63,521,677 | 135 bp | At TSS Multiome | 712 | |
| chr20:63,537,759–63,538,455 | 17.3 kb | Distal (>10kb) Multiome | 823 | |
| chr20:63,552,551–63,554,733 | 32.8 kb | Distal (>10kb) Multiome | 544 | |
| chr20:63,573,969–63,574,596 | 53.5 kb | Distal (>10kb) Multiome | 551 | |
| chr20:63,626,480–63,627,647 | 106.3 kb | Distal (>10kb) Multiome | 982 | |
| chr20:63,641,266–63,642,913 | 121.3 kb | Distal (>10kb) Multiome | 691 | |
| chr20:63,652,233–63,654,166 | 132.8 kb | Distal (>10kb) Multiome | 1011 | |
| chr20:63,657,813–63,658,939 | 137.7 kb | Distal (>10kb) Multiome | 1055 | |
| chr20:63,696,254–63,697,070 | 175.8 kb | Distal (>10kb) Multiome | 458 | |
| chr20:63,707,489–63,708,488 | 187.2 kb | Distal (>10kb) Multiome | 1008 | |
| chr20:63,737,573–63,741,470 | 218.9 kb | Distal (>10kb) Multiome | 1098 | |
| chr20:63,775,216–63,775,997 | 254.7 kb | Distal (>10kb) Multiome | 257 |
Genomic view of the PPDPF locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.