The protein encoded by this gene is a member of the inorganic pyrophosphatase (PPase) family. PPases catalyze the hydrolysis of pyrophosphate to inorganic phosphate, which is important for the phosphate metabolism of cells. Studies of a similar protein in bovine suggested a cytoplasmic localization of this enzyme. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PPA1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPA1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPA1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:70,052,471–70,054,619 | 180.7 kb | Distal (>10kb) Multiome | 577 | |
| chr10:70,075,065–70,075,566 | 158.2 kb | Distal (>10kb) Multiome | 23 | |
| chr10:70,116,082–70,116,892 | 117.0 kb | Distal (>10kb) Multiome | 217 | |
| chr10:70,132,124–70,133,061 | 100.7 kb | Distal (>10kb) Multiome | 729 | |
| chr10:70,145,328–70,147,235 | 87.8 kb | Distal (>10kb) Multiome | 1006 | |
| chr10:70,169,902–70,171,034 | 62.8 kb | Distal (>10kb) Multiome | 777 | |
| chr10:70,232,204–70,234,260 | 179 bp | At TSS Multiome | 949 | |
| chr10:70,381,835–70,383,091 | 149.3 kb | Distal (>10kb) Multiome | 693 | |
| chr10:70,403,687–70,404,709 | 170.7 kb | Distal (>10kb) Multiome | 788 | |
| chr10:70,437,649–70,438,147 | 204.5 kb | Distal (>10kb) Multiome | 93 | |
| chr10:70,439,787–70,443,007 | 209.2 kb | Distal (>10kb) Multiome | 501 | |
| chr10:70,455,031–70,455,839 | 222.0 kb | Distal (>10kb) Multiome | 196 | |
| chr10:70,458,264–70,459,984 | 225.2 kb | Distal (>10kb) Multiome | 310 | |
| chr10:70,478,010–70,479,323 | 245.3 kb | Distal (>10kb) Multiome | 492 |
Genomic view of the PPA1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.