POLRMT

RNA polymerase mitochondrial | APOLMT, MTRNAP, MTRPOL, h-mtRPOL

This gene encodes a mitochondrial DNA-directed RNA polymerase. The gene product is responsible for mitochondrial gene expression as well as for providing RNA primers for initiation of replication of the mitochondrial genome. Although this polypeptide has the same function as the three nuclear DNA-directed RNA polymerases, it is more closely related to RNA polymerases of phage and mitochondrial polymerases of lower eukaryotes. [provided by RefSeq, Jul 2008]

Biological processes 28 terms

3'-5'-RNA exonuclease activity (GO:0000175)5'-3' RNA polymerase activity (GO:0034062)DNA binding (GO:0003677)DNA-directed RNA polymerase activity (GO:0003899)DNA-directed RNA polymerase activity (GO:0003899)DNA-directed RNA polymerase activity (GO:0003899)DNA-directed RNA polymerase activity (GO:0003899)DNA-templated transcription (GO:0006351)RNA binding (GO:0003723)mitochondrial DNA replication (GO:0006264)mitochondrial DNA-directed RNA polymerase complex (GO:0034245)mitochondrial matrix (GO:0005759)mitochondrial matrix (GO:0005759)mitochondrial matrix (GO:0005759)mitochondrial nucleoid (GO:0042645)mitochondrial promoter sequence-specific DNA binding (GO:0001018)mitochondrial transcription (GO:0006390)mitochondrial transcription (GO:0006390)mitochondrial transcription (GO:0006390)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion (GO:0005739)protein binding (GO:0005515)protein-containing complex (GO:0032991)protein-containing complex (GO:0032991)sequence-specific DNA binding (GO:0043565)sequence-specific DNA binding (GO:0043565)transcription initiation at mitochondrial promoter (GO:0006391)

Expression (TPM)

TFs regulating POLRMT 0 TFs

Transcription factors with Perturb-seq knockdown data for POLRMT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = POLRMT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to POLRMT

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of POLRMT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:343,939–345,411	288.8 kb	Distal (>10kb) Multiome	600
chr19:408,569–409,459	224.4 kb	Distal (>10kb) Multiome	310
chr19:459,789–461,382	173.3 kb	Distal (>10kb) Multiome	545
chr19:461,557–462,453	171.5 kb	Distal (>10kb) Multiome	580
chr19:488,399–489,918	144.4 kb	Distal (>10kb) Multiome	898
chr19:506,451–508,366	126.4 kb	Distal (>10kb) Multiome	1001
chr19:510,509–511,797	122.7 kb	Distal (>10kb) Multiome	739
chr19:518,865–519,356	114.4 kb	Distal (>10kb) Multiome	151
chr19:530,809–533,397	102.1 kb	Distal (>10kb) Multiome	856
chr19:572,071–573,594	61.1 kb	Distal (>10kb) Multiome	888
chr19:588,127–589,976	45.2 kb	Distal (>10kb) Multiome	526
chr19:632,653–633,806	79 bp	At TSS Multiome	758
chr19:639,456–640,331	6.2 kb	Proximal (<10kb) Multiome	389
chr19:662,267–663,864	29.8 kb	Distal (>10kb) Multiome	723
chr19:679,616–681,731	47.2 kb	Distal (>10kb) Multiome	832
chr19:703,387–704,718	70.5 kb	Distal (>10kb) Multiome	586
chr19:708,425–709,293	75.3 kb	Distal (>10kb) Multiome	317
chr19:796,668–798,362	163.7 kb	Distal (>10kb) Multiome	956
chr19:821,294–822,728	188.6 kb	Distal (>10kb) Multiome	254
chr19:861,664–863,223	228.7 kb	Distal (>10kb) Multiome	530
chr19:892,703–893,746	259.7 kb	Distal (>10kb) Multiome	715
chr19:917,038–918,169	284.3 kb	Distal (>10kb) Multiome	711
chr19:924,743–926,242	292.2 kb	Distal (>10kb) Multiome	796
chr19:927,058–927,629	293.8 kb	Distal (>10kb) Multiome	362

Genome Browser

Genomic view of the POLRMT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.