Predicted to enable chromatin binding activity. Involved in transcription by RNA polymerase III. Located in nucleus. Part of RNA polymerase III complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for POLR3GL. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = POLR3GL upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of POLR3GL, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:145,707,296–145,708,738 | 256.5 kb | Distal (>10kb) Multiome | 511 | |
| chr1:145,720,881–145,721,650 | 243.4 kb | Distal (>10kb) Multiome | 548 | |
| chr1:145,823,605–145,824,539 | 140.6 kb | Distal (>10kb) Multiome | 899 | |
| chr1:145,845,315–145,846,128 | 119.0 kb | Distal (>10kb) Multiome | 750 | |
| chr1:145,858,348–145,860,193 | 104.7 kb | Distal (>10kb) Multiome | 828 | |
| chr1:145,885,653–145,886,460 | 78.6 kb | Distal (>10kb) Multiome | 327 | |
| chr1:145,891,718–145,892,684 | 72.6 kb | Distal (>10kb) Multiome | 738 | |
| chr1:145,918,087–145,919,947 | 45.8 kb | Distal (>10kb) Multiome | 724 | |
| chr1:145,926,848–145,927,896 | 37.2 kb | Distal (>10kb) Multiome | 890 | |
| chr1:145,932,283–145,933,321 | 31.9 kb | Distal (>10kb) Multiome | 308 | |
| chr1:145,957,545–145,958,280 | 6.7 kb | Proximal (<10kb) Multiome | 631 | |
| chr1:145,960,287–145,961,311 | 4.0 kb | Proximal (<10kb) Multiome | 498 | |
| chr1:145,964,302–145,964,971 | 49 bp | At TSS Multiome | 662 | |
| chr1:145,978,977–145,980,010 | 14.8 kb | Distal (>10kb) Multiome | 689 | |
| chr1:145,996,493–145,997,058 | 32.0 kb | Distal (>10kb) Multiome | 911 | |
| chr1:146,035,364–146,036,312 | 71.0 kb | Distal (>10kb) Multiome | 845 | |
| chr1:146,036,931–146,039,723 | 72.4 kb | Distal (>10kb) Multiome | 1048 | |
| chr1:146,051,092–146,052,696 | 87.6 kb | Distal (>10kb) Multiome | 1182 |
Genomic view of the POLR3GL locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.