Enables chromatin binding activity. Involved in positive regulation of innate immune response; positive regulation of interferon-beta production; and transcription by RNA polymerase III. Acts upstream of or within cell population proliferation. Located in cytosol and nuclear body. Part of RNA polymerase III complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for POLR3G. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = POLR3G upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of POLR3G, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:90,408,713–90,410,622 | 65.0 kb | Distal (>10kb) Multiome | 999 | |
| chr5:90,473,267–90,475,425 | 178 bp | At TSS Multiome | 1125 | |
| chr5:90,476,143–90,476,896 | 1.3 kb | Proximal (<10kb) | 42 | |
| chr5:90,476,971–90,477,623 | 2.4 kb | Proximal (<10kb) Multiome | 165 | |
| chr5:90,528,730–90,530,341 | 54.8 kb | Distal (>10kb) Multiome | 946 | |
| chr5:90,557,815–90,559,398 | 83.9 kb | Distal (>10kb) Multiome | 611 |
Genomic view of the POLR3G locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.