Predicted to be involved in DNA-templated transcription; defense response to virus; and innate immune response. Located in nucleoplasm. Part of RNA polymerase III complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for POLR3E. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = POLR3E upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of POLR3E, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:22,007,549–22,008,682 | 289.4 kb | Distal (>10kb) Multiome | 685 | |
| chr16:22,189,506–22,191,692 | 106.5 kb | Distal (>10kb) Multiome HiCAR | 989 | |
| chr16:22,195,474–22,196,347 | 101.5 kb | Distal (>10kb) Multiome HiCAR | 886 | |
| chr16:22,205,924–22,206,847 | 91.1 kb | Distal (>10kb) Multiome HiCAR | 1038 | |
| chr16:22,296,790–22,298,718 | 1.2 kb | Proximal (<10kb) Multiome | 1288 | |
| chr16:22,373,797–22,375,383 | 77.3 kb | Distal (>10kb) Multiome | 951 | |
| chr16:22,436,881–22,437,622 | 139.7 kb | Distal (>10kb) Multiome | 642 |
Genomic view of the POLR3E locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.