This gene encodes a subunit of a specific form of RNA polymerase II termed Pol II(G). The encoded protein may act as a negative regulator of transcriptional activation by the Mediator complex. Alternative splicing results in multiple transcript variants. There is a pseudogene for this gene on chromosome 4. Readthrough transcription between this gene and the neighboring upstream gene MYZAP (myocardial zonula adherens protein) is represented with GeneID 145781. [provided by RefSeq, Oct 2013]
Transcription factors with Perturb-seq knockdown data for POLR2M. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = POLR2M upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of POLR2M, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:57,411,681–57,412,959 | 294.3 kb | Distal (>10kb) Multiome | 165 | |
| chr15:57,477,799–57,478,810 | 228.4 kb | Distal (>10kb) Multiome | 603 | |
| chr15:57,495,641–57,496,411 | 210.6 kb | Distal (>10kb) Multiome | 71 | |
| chr15:57,501,832–57,502,700 | 204.5 kb | Distal (>10kb) Multiome | 59 | |
| chr15:57,591,431–57,592,312 | 114.8 kb | Distal (>10kb) Multiome | 318 | |
| chr15:57,706,507–57,707,248 | 35 bp | At TSS Multiome | 821 |
Genomic view of the POLR2M locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.