POLR2K

RNA polymerase II, I and III subunit K | RPB10alpha, RPB12

This gene encodes one of the smallest subunits of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases. [provided by RefSeq, Jul 2008]

Member of: DE-1 DE-1.25 Developmental clusters: GC5

Biological processes 34 terms

DNA binding (GO:0003677)DNA-directed RNA polymerase activity (GO:0003899)DNA-directed RNA polymerase activity (GO:0003899)DNA-templated transcription (GO:0006351)RNA polymerase I complex (GO:0005736)RNA polymerase I complex (GO:0005736)RNA polymerase II, core complex (GO:0005665)RNA polymerase II, core complex (GO:0005665)RNA polymerase III complex (GO:0005666)RNA polymerase III complex (GO:0005666)cytosol (GO:0005829)fibrillar center (GO:0001650)nucleolar large rRNA transcription by RNA polymerase I (GO:0042790)nucleolus (GO:0005730)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)protein binding (GO:0005515)regulation of transcription by RNA polymerase I (GO:0006356)termination of RNA polymerase I transcription (GO:0006363)termination of RNA polymerase III transcription (GO:0006386)transcription by RNA polymerase II (GO:0006366)transcription by RNA polymerase II (GO:0006366)transcription by RNA polymerase III (GO:0006383)transcription by RNA polymerase III (GO:0006383)transcription elongation by RNA polymerase I (GO:0006362)transcription elongation by RNA polymerase II (GO:0006368)transcription initiation at RNA polymerase I promoter (GO:0006361)transcription initiation at RNA polymerase II promoter (GO:0006367)transcription initiation at RNA polymerase III promoter (GO:0006384)zinc ion binding (GO:0008270)zinc ion binding (GO:0008270)

Expression (TPM)

TFs regulating POLR2K 0 TFs

Transcription factors with Perturb-seq knockdown data for POLR2K. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = POLR2K upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to POLR2K

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of POLR2K, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr8:99,892,915–99,894,104	257.0 kb	Distal (>10kb) Multiome	817
chr8:100,105,612–100,106,523	44.5 kb	Distal (>10kb) Multiome	186
chr8:100,143,984–100,144,357	6.3 kb	Proximal (<10kb)	387
chr8:100,145,361–100,146,165	4.8 kb	Proximal (<10kb) Multiome	584
chr8:100,149,973–100,150,933	76 bp	At TSS Multiome	732
chr8:100,157,695–100,158,647	7.6 kb	Proximal (<10kb) Multiome	728
chr8:100,212,742–100,213,750	62.5 kb	Distal (>10kb) Multiome	792
chr8:100,309,111–100,310,745	159.5 kb	Distal (>10kb) Multiome	964
chr8:100,335,686–100,336,642	185.6 kb	Distal (>10kb) Multiome	284
chr8:100,375,327–100,376,046	225.1 kb	Distal (>10kb) Multiome	241
chr8:100,559,150–100,560,136	409.1 kb	Distal (>10kb) Multiome HiCAR	918

Genome Browser

Genomic view of the POLR2K locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.