POLR2I

RNA polymerase II subunit I | RPB9, hRPB14.5

This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit, in combination with two other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. The product of this gene has two zinc finger motifs with conserved cysteines and the subunit does possess zinc binding activity. [provided by RefSeq, Jul 2008]

Member of: DE-1 DE-1.55

Biological processes 21 terms

DNA-directed RNA polymerase activity (GO:0003899)DNA-directed RNA polymerase activity (GO:0003899)DNA-directed RNA polymerase activity (GO:0003899)DNA-templated transcription (GO:0006351)RNA polymerase II, core complex (GO:0005665)RNA polymerase II, core complex (GO:0005665)RNA polymerase II, core complex (GO:0005665)maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II (GO:0001193)nucleic acid binding (GO:0003676)nucleolus (GO:0005730)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)protein binding (GO:0005515)transcription by RNA polymerase II (GO:0006366)transcription elongation by RNA polymerase II (GO:0006368)transcription initiation at RNA polymerase II promoter (GO:0006367)transcription initiation at RNA polymerase II promoter (GO:0006367)transcription-coupled nucleotide-excision repair (GO:0006283)zinc ion binding (GO:0008270)zinc ion binding (GO:0008270)

Expression (TPM)

TFs regulating POLR2I 0 TFs

Transcription factors with Perturb-seq knockdown data for POLR2I. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = POLR2I upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to POLR2I

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of POLR2I, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:35,860,621–35,861,651	253.6 kb	Distal (>10kb) Multiome	299
chr19:35,868,369–35,868,860	246.4 kb	Distal (>10kb) Multiome	320
chr19:35,869,343–35,870,482	245.0 kb	Distal (>10kb) Multiome	492
chr19:35,899,240–35,900,760	215.2 kb	Distal (>10kb) Multiome	751
chr19:35,931,342–35,932,167	183.2 kb	Distal (>10kb) Multiome	835
chr19:35,936,083–35,936,704	178.5 kb	Distal (>10kb) Multiome	417
chr19:35,986,945–35,987,622	127.6 kb	Distal (>10kb) Multiome	363
chr19:35,994,796–35,995,940	119.7 kb	Distal (>10kb) Multiome	897
chr19:36,008,519–36,009,006	106.1 kb	Distal (>10kb) Multiome	427
chr19:36,013,972–36,014,810	100.5 kb	Distal (>10kb) Multiome	623
chr19:36,032,424–36,033,187	82.0 kb	Distal (>10kb) Multiome	179
chr19:36,053,782–36,055,591	60.4 kb	Distal (>10kb) Multiome	1026
chr19:36,113,981–36,116,196	367 bp	At TSS Multiome	1052
chr19:36,127,575–36,128,707	13.1 kb	Distal (>10kb) Multiome	942
chr19:36,139,425–36,141,811	26.4 kb	Distal (>10kb) Multiome	1037
chr19:36,160,493–36,161,405	46.0 kb	Distal (>10kb) Multiome	94
chr19:36,214,162–36,215,543	99.9 kb	Distal (>10kb) Multiome	1008
chr19:36,245,106–36,245,849	130.5 kb	Distal (>10kb) Multiome	153
chr19:36,331,415–36,332,377	216.9 kb	Distal (>10kb) Multiome	372
chr19:36,378,606–36,379,573	264.2 kb	Distal (>10kb) Multiome	839

Genome Browser

Genomic view of the POLR2I locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.