POLR2F

RNA polymerase II, I and III subunit F | HRBP14.4, RPB6

This gene encodes the sixth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. In yeast, this polymerase subunit, in combination with at least two other subunits, forms a structure that stabilizes the transcribing polymerase on the DNA template. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Member of: DE-1 DE-1.41

Biological processes 32 terms

DNA binding (GO:0003677)DNA-directed RNA polymerase activity (GO:0003899)DNA-directed RNA polymerase activity (GO:0003899)DNA-templated transcription (GO:0006351)RNA polymerase I complex (GO:0005736)RNA polymerase I complex (GO:0005736)RNA polymerase II, core complex (GO:0005665)RNA polymerase II, core complex (GO:0005665)RNA polymerase II, core complex (GO:0005665)RNA polymerase III complex (GO:0005666)RNA polymerase III complex (GO:0005666)cytosol (GO:0005829)fibrillar center (GO:0001650)nucleolar large rRNA transcription by RNA polymerase I (GO:0042790)nucleolus (GO:0005730)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)tRNA transcription by RNA polymerase III (GO:0042797)termination of RNA polymerase I transcription (GO:0006363)termination of RNA polymerase III transcription (GO:0006386)transcription by RNA polymerase I (GO:0006360)transcription by RNA polymerase II (GO:0006366)transcription by RNA polymerase II (GO:0006366)transcription by RNA polymerase III (GO:0006383)transcription elongation by RNA polymerase I (GO:0006362)transcription elongation by RNA polymerase II (GO:0006368)transcription initiation at RNA polymerase I promoter (GO:0006361)transcription initiation at RNA polymerase II promoter (GO:0006367)transcription initiation at RNA polymerase III promoter (GO:0006384)

Expression (TPM)

TFs regulating POLR2F 0 TFs

Transcription factors with Perturb-seq knockdown data for POLR2F. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = POLR2F upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to POLR2F

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of POLR2F, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr22:37,658,172–37,659,508	295.1 kb	Distal (>10kb) Multiome	722
chr22:37,674,916–37,675,641	278.3 kb	Distal (>10kb) Multiome	607
chr22:37,676,590–37,677,674	276.5 kb	Distal (>10kb) Multiome	655
chr22:37,686,104–37,686,784	267.3 kb	Distal (>10kb) Multiome	866
chr22:37,696,496–37,697,685	256.8 kb	Distal (>10kb) Multiome	428
chr22:37,745,641–37,746,995	207.5 kb	Distal (>10kb) Multiome	627
chr22:37,802,124–37,802,989	151.3 kb	Distal (>10kb) Multiome	603
chr22:37,804,679–37,805,768	148.5 kb	Distal (>10kb) Multiome	763
chr22:37,807,436–37,808,267	145.9 kb	Distal (>10kb) Multiome	766
chr22:37,817,672–37,819,114	135.8 kb	Distal (>10kb) Multiome	713
chr22:37,824,524–37,825,593	128.7 kb	Distal (>10kb) Multiome	173
chr22:37,843,748–37,844,743	109.3 kb	Distal (>10kb) Multiome	798
chr22:37,849,215–37,849,709	104.3 kb	Distal (>10kb) Multiome	753
chr22:37,905,849–37,906,846	47.4 kb	Distal (>10kb) Multiome	552
chr22:37,933,777–37,934,256	19.6 kb	Distal (>10kb) Multiome	679
chr22:37,953,153–37,954,120	44 bp	At TSS Multiome	617
chr22:37,983,021–37,985,110	30.7 kb	Distal (>10kb) Multiome	228
chr22:38,052,312–38,052,803	98.8 kb	Distal (>10kb) Multiome	529
chr22:38,057,008–38,057,702	103.6 kb	Distal (>10kb) Multiome	656
chr22:38,080,912–38,081,618	127.4 kb	Distal (>10kb) Multiome	175
chr22:38,097,697–38,098,236	144.3 kb	Distal (>10kb) Multiome	186
chr22:38,181,365–38,182,291	228.2 kb	Distal (>10kb) Multiome	676
chr22:38,201,378–38,203,636	248.2 kb	Distal (>10kb) Multiome	848
chr22:38,214,397–38,215,017	261.1 kb	Distal (>10kb) Multiome	382

Genome Browser

Genomic view of the POLR2F locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.