This gene encodes a DNA-directed RNA polymerase I subunit. The encoded protein contains two potential zinc-binding motifs and may play a role in regulation of cell proliferation. The encoded protein may be involved in cancer and human immunodeficiency virus progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Transcription factors with Perturb-seq knockdown data for POLR1H. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = POLR1H upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of POLR1H, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:29,926,526–29,927,449 | 134.1 kb | Distal (>10kb) Multiome | 372 | |
| chr6:30,006,934–30,007,571 | 54.0 kb | Distal (>10kb) Multiome | 195 | |
| chr6:30,060,737–30,061,999 | at TSS | At TSS Multiome | 973 | |
| chr6:30,066,588–30,067,716 | 5.9 kb | Proximal (<10kb) Multiome | 952 | |
| chr6:30,101,800–30,102,573 | 40.9 kb | Distal (>10kb) Multiome | 644 | |
| chr6:30,103,094–30,103,626 | 42.1 kb | Distal (>10kb) Multiome | 616 | |
| chr6:30,171,597–30,172,574 | 110.7 kb | Distal (>10kb) Multiome | 185 | |
| chr6:30,207,044–30,207,811 | 146.1 kb | Distal (>10kb) Multiome | 514 | |
| chr6:30,212,953–30,213,888 | 152.2 kb | Distal (>10kb) Multiome | 826 | |
| chr6:30,213,977–30,214,728 | 153.3 kb | Distal (>10kb) Multiome | 758 | |
| chr6:30,259,131–30,260,199 | 198.3 kb | Distal (>10kb) Multiome | 475 | |
| chr6:30,325,606–30,327,611 | 265.7 kb | Distal (>10kb) Multiome | 1043 | |
| chr6:30,344,843–30,345,715 | 284.0 kb | Distal (>10kb) Multiome | 892 | |
| chr6:30,357,696–30,358,238 | 296.6 kb | Distal (>10kb) Multiome | 207 |
Genomic view of the POLR1H locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.