Predicted to enable DNA binding activity and RNA polymerase I general transcription initiation factor binding activity. Involved in nucleolar large rRNA transcription by RNA polymerase I and transcription initiation at RNA polymerase I promoter. Located in fibrillar center and nucleoplasm. Part of RNA polymerase I complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for POLR1E. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = POLR1E upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of POLR1E, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:37,415,054–37,415,560 | 70.6 kb | Distal (>10kb) Multiome | 414 | |
| chr9:37,422,138–37,423,121 | 63.3 kb | Distal (>10kb) Multiome | 814 | |
| chr9:37,464,634–37,466,782 | 20.4 kb | Distal (>10kb) Multiome | 997 | |
| chr9:37,482,376–37,482,603 | 3.3 kb | Proximal (<10kb) | 150 | |
| chr9:37,485,291–37,486,541 | 67 bp | At TSS Multiome | 734 | |
| chr9:37,575,608–37,576,724 | 90.4 kb | Distal (>10kb) Multiome | 608 | |
| chr9:37,592,006–37,592,956 | 106.6 kb | Distal (>10kb) Multiome | 990 | |
| chr9:37,650,357–37,651,703 | 165.0 kb | Distal (>10kb) Multiome | 403 | |
| chr9:37,751,142–37,751,941 | 265.6 kb | Distal (>10kb) Multiome | 38 | |
| chr9:37,753,624–37,754,122 | 267.9 kb | Distal (>10kb) Multiome | 540 | |
| chr9:37,784,663–37,785,433 | 299.1 kb | Distal (>10kb) Multiome | 859 |
Genomic view of the POLR1E locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.