Enables several functions, including catalytic activity, acting on DNA; identical protein binding activity; and magnesium ion binding activity. Involved in DNA metabolic process; negative regulation of double-strand break repair via homologous recombination; and protein homooligomerization. Located in Golgi apparatus; cytosol; and nucleoplasm. Is active in mitochondrial nucleoid; nucleus; and site of double-strand break. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for POLQ. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = POLQ upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of POLQ, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:121,545,326–121,546,305 | 39 bp | At TSS Multiome | 673 | |
| chr3:121,546,759–121,547,196 | 771 bp | At TSS | 224 | |
| chr3:121,593,261–121,593,964 | 47.6 kb | Distal (>10kb) Multiome | 230 | |
| chr3:121,749,162–121,750,214 | 203.8 kb | Distal (>10kb) Multiome | 874 | |
| chr3:121,834,395–121,835,766 | 289.2 kb | Distal (>10kb) Multiome | 839 | |
| chr3:122,382,880–122,383,692 | 837.1 kb | Distal (>10kb) Multiome HiCAR | 711 | |
| chr3:122,383,843–122,384,747 | 838.3 kb | Distal (>10kb) Multiome HiCAR | 937 |
Genomic view of the POLQ locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.