Predicted to enable DNA-directed DNA polymerase activity. Predicted to be involved in double-strand break repair via nonhomologous end joining. Predicted to act upstream of or within B cell differentiation and somatic hypermutation of immunoglobulin genes. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for POLM. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = POLM upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of POLM, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:43,838,582–43,839,204 | 243.5 kb | Distal (>10kb) Multiome | 647 | |
| chr7:43,868,905–43,870,110 | 213.0 kb | Distal (>10kb) Multiome | 804 | |
| chr7:43,905,962–43,907,078 | 175.9 kb | Distal (>10kb) Multiome | 557 | |
| chr7:43,926,113–43,927,072 | 156.0 kb | Distal (>10kb) Multiome | 1004 | |
| chr7:43,985,975–43,986,501 | 96.2 kb | Distal (>10kb) Multiome | 113 | |
| chr7:44,018,938–44,019,667 | 63.3 kb | Distal (>10kb) Multiome | 564 | |
| chr7:44,038,952–44,039,494 | 43.3 kb | Distal (>10kb) Multiome | 215 | |
| chr7:44,044,335–44,045,323 | 37.8 kb | Distal (>10kb) Multiome | 832 | |
| chr7:44,063,611–44,064,251 | 18.5 kb | Distal (>10kb) Multiome | 121 | |
| chr7:44,065,163–44,066,086 | 16.6 kb | Distal (>10kb) Multiome | 198 | |
| chr7:44,072,381–44,072,599 | 9.9 kb | Proximal (<10kb) | 310 | |
| chr7:44,081,995–44,083,183 | 152 bp | At TSS Multiome | 909 | |
| chr7:44,103,745–44,105,419 | 21.8 kb | Distal (>10kb) Multiome | 267 | |
| chr7:44,112,627–44,113,466 | 30.5 kb | Distal (>10kb) Multiome | 237 | |
| chr7:44,123,183–44,124,199 | 41.1 kb | Distal (>10kb) Multiome | 814 | |
| chr7:44,145,408–44,146,956 | 63.7 kb | Distal (>10kb) Multiome | 347 | |
| chr7:44,200,748–44,201,465 | 118.4 kb | Distal (>10kb) Multiome | 738 | |
| chr7:44,218,223–44,218,706 | 135.9 kb | Distal (>10kb) Multiome | 215 | |
| chr7:44,275,748–44,276,529 | 193.7 kb | Distal (>10kb) Multiome | 146 | |
| chr7:44,309,084–44,310,124 | 227.3 kb | Distal (>10kb) Multiome | 263 | |
| chr7:44,325,052–44,325,687 | 242.9 kb | Distal (>10kb) Multiome | 118 |
Genomic view of the POLM locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.