This gene encodes a DNA polymerase. DNA polymerases catalyze DNA-template-directed extension of the 3'-end of a DNA strand. This particular polymerase, which is a member of the X family of DNA polymerases, likely plays a role in non-homologous end joining and other DNA repair processes. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2010]
Transcription factors with Perturb-seq knockdown data for POLL. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = POLL upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of POLL, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:101,282,747–101,283,297 | 305.1 kb | Distal (>10kb) Multiome HiCAR | 74 | |
| chr10:101,285,534–101,286,046 | 302.2 kb | Distal (>10kb) Multiome HiCAR | 150 | |
| chr10:101,288,327–101,289,007 | 299.5 kb | Distal (>10kb) Multiome HiCAR | 96 | |
| chr10:101,291,317–101,293,346 | 296.3 kb | Distal (>10kb) Multiome | 433 | |
| chr10:101,311,194–101,311,678 | 276.8 kb | Distal (>10kb) Multiome | 94 | |
| chr10:101,353,481–101,354,935 | 234.1 kb | Distal (>10kb) Multiome | 875 | |
| chr10:101,450,379–101,450,896 | 137.5 kb | Distal (>10kb) Multiome | 226 | |
| chr10:101,569,467–101,571,017 | 17.8 kb | Distal (>10kb) Multiome | 558 | |
| chr10:101,587,742–101,588,624 | 104 bp | At TSS Multiome | 673 | |
| chr10:101,597,095–101,597,276 | 9.0 kb | Proximal (<10kb) | 36 | |
| chr10:101,602,717–101,603,282 | 14.8 kb | Distal (>10kb) Multiome | 348 | |
| chr10:101,606,618–101,607,814 | 19.1 kb | Distal (>10kb) Multiome | 143 | |
| chr10:101,667,996–101,669,307 | 80.6 kb | Distal (>10kb) Multiome | 135 | |
| chr10:101,694,020–101,695,446 | 106.2 kb | Distal (>10kb) Multiome | 821 | |
| chr10:101,749,494–101,750,047 | 161.6 kb | Distal (>10kb) Multiome | 178 | |
| chr10:101,775,454–101,777,009 | 188.3 kb | Distal (>10kb) Multiome HiCAR | 202 | |
| chr10:101,778,233–101,781,743 | 193.1 kb | Distal (>10kb) Multiome HiCAR | 720 | |
| chr10:101,782,912–101,783,976 | 195.3 kb | Distal (>10kb) Multiome HiCAR | 661 | |
| chr10:101,817,350–101,819,352 | 230.5 kb | Distal (>10kb) Multiome | 1004 | |
| chr10:101,828,926–101,831,154 | 242.7 kb | Distal (>10kb) Multiome | 697 | |
| chr10:101,839,408–101,839,998 | 251.5 kb | Distal (>10kb) Multiome | 196 | |
| chr10:101,840,663–101,841,471 | 252.9 kb | Distal (>10kb) Multiome | 499 | |
| chr10:101,843,178–101,844,328 | 255.7 kb | Distal (>10kb) Multiome | 277 |
Genomic view of the POLL locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.