This gene encodes a protein that interacts with the DNA polymerase delta p50 subunit, as well as with proliferating cell nuclear antigen. The encoded protein maybe play a role in the ability of the replication fork to bypass DNA lesions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Transcription factors with Perturb-seq knockdown data for POLDIP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = POLDIP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of POLDIP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:28,227,184–28,228,835 | 129.8 kb | Distal (>10kb) Multiome | 426 | |
| chr17:28,251,169–28,251,939 | 106.0 kb | Distal (>10kb) Multiome | 480 | |
| chr17:28,317,975–28,319,646 | 38.5 kb | Distal (>10kb) Multiome | 858 | |
| chr17:28,321,010–28,321,937 | 36.1 kb | Distal (>10kb) Multiome | 25 | |
| chr17:28,335,024–28,336,772 | 21.9 kb | Distal (>10kb) Multiome | 933 | |
| chr17:28,357,059–28,357,929 | 21 bp | At TSS Multiome | 878 | |
| chr17:28,371,118–28,372,519 | 14.0 kb | Distal (>10kb) Multiome | 532 | |
| chr17:28,381,316–28,381,844 | 24.1 kb | Distal (>10kb) Multiome | 159 | |
| chr17:28,405,673–28,406,384 | 48.4 kb | Distal (>10kb) Multiome | 591 | |
| chr17:28,466,531–28,467,034 | 109.3 kb | Distal (>10kb) Multiome | 179 | |
| chr17:28,551,965–28,553,140 | 195.1 kb | Distal (>10kb) Multiome | 557 | |
| chr17:28,570,861–28,571,983 | 214.0 kb | Distal (>10kb) Multiome | 701 | |
| chr17:28,576,649–28,577,524 | 219.5 kb | Distal (>10kb) Multiome | 652 | |
| chr17:28,598,491–28,599,842 | 241.6 kb | Distal (>10kb) Multiome | 810 | |
| chr17:28,621,936–28,622,562 | 264.8 kb | Distal (>10kb) Multiome | 55 | |
| chr17:28,644,541–28,645,596 | 287.7 kb | Distal (>10kb) Multiome | 795 |
Genomic view of the POLDIP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.