This gene encodes the smallest subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein enhances the activity of DNA polymerase delta and plays a role in fork repair and stabilization through interactions with the DNA helicase Bloom syndrome protein. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
Transcription factors with Perturb-seq knockdown data for POLD4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = POLD4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of POLD4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:67,056,596–67,057,312 | 296.7 kb | Distal (>10kb) Multiome | 382 | |
| chr11:67,071,470–67,071,999 | 281.8 kb | Distal (>10kb) Multiome | 302 | |
| chr11:67,117,553–67,120,314 | 234.5 kb | Distal (>10kb) Multiome | 762 | |
| chr11:67,239,493–67,240,241 | 113.7 kb | Distal (>10kb) Multiome | 792 | |
| chr11:67,265,898–67,267,077 | 87.1 kb | Distal (>10kb) Multiome | 471 | |
| chr11:67,288,260–67,289,971 | 64.4 kb | Distal (>10kb) Multiome | 985 | |
| chr11:67,302,488–67,304,170 | 50.2 kb | Distal (>10kb) Multiome | 661 | |
| chr11:67,316,992–67,318,501 | 35.9 kb | Distal (>10kb) Multiome | 918 | |
| chr11:67,348,447–67,348,710 | 4.9 kb | Proximal (<10kb) | 265 | |
| chr11:67,351,267–67,351,470 | 2.1 kb | Proximal (<10kb) | 213 | |
| chr11:67,352,967–67,354,228 | 95 bp | At TSS Multiome | 781 | |
| chr11:67,356,925–67,357,362 | 3.3 kb | Proximal (<10kb) | 455 | |
| chr11:67,372,171–67,373,596 | 19.5 kb | Distal (>10kb) Multiome | 497 | |
| chr11:67,391,276–67,392,428 | 38.3 kb | Distal (>10kb) Multiome | 957 | |
| chr11:67,401,038–67,402,351 | 48.3 kb | Distal (>10kb) Multiome | 741 | |
| chr11:67,420,418–67,421,666 | 67.7 kb | Distal (>10kb) Multiome | 648 | |
| chr11:67,428,036–67,428,950 | 74.8 kb | Distal (>10kb) Multiome | 813 | |
| chr11:67,443,182–67,444,063 | 90.1 kb | Distal (>10kb) Multiome | 612 | |
| chr11:67,464,410–67,465,252 | 111.2 kb | Distal (>10kb) Multiome | 710 | |
| chr11:67,468,551–67,469,666 | 115.7 kb | Distal (>10kb) Multiome | 774 | |
| chr11:67,482,830–67,483,745 | 129.6 kb | Distal (>10kb) Multiome | 969 | |
| chr11:67,504,073–67,506,408 | 152.7 kb | Distal (>10kb) Multiome | 769 | |
| chr11:67,507,504–67,509,030 | 154.8 kb | Distal (>10kb) Multiome | 897 | |
| chr11:67,583,474–67,584,777 | 230.1 kb | Distal (>10kb) Multiome | 633 | |
| chr11:67,606,302–67,607,213 | 253.3 kb | Distal (>10kb) Multiome | 781 | |
| chr11:67,614,064–67,614,626 | 260.7 kb | Distal (>10kb) Multiome | 383 | |
| chr11:67,619,429–67,620,391 | 266.2 kb | Distal (>10kb) Multiome | 50 | |
| chr11:67,628,876–67,631,242 | 276.8 kb | Distal (>10kb) Multiome | 1018 |
Genomic view of the POLD4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.