The protein encoded by this gene is a DNA polymerase involved in base excision and repair, also called gap-filling DNA synthesis. The encoded protein, acting as a monomer, is normally found in the cytoplasm, but it translocates to the nucleus upon DNA damage. Several transcript variants of this gene exist, but the full-length nature of only one has been described to date. [provided by RefSeq, Sep 2011]
Transcription factors with Perturb-seq knockdown data for POLB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = POLB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of POLB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:42,050,725–42,052,921 | 286.3 kb | Distal (>10kb) Multiome | 1042 | |
| chr8:42,139,747–42,140,990 | 197.8 kb | Distal (>10kb) Multiome | 779 | |
| chr8:42,151,983–42,153,808 | 185.6 kb | Distal (>10kb) Multiome | 975 | |
| chr8:42,270,718–42,271,870 | 67.2 kb | Distal (>10kb) Multiome | 668 | |
| chr8:42,337,948–42,339,165 | 38 bp | At TSS Multiome | 710 | |
| chr8:42,376,919–42,377,769 | 38.8 kb | Distal (>10kb) Multiome | 159 | |
| chr8:42,391,151–42,392,597 | 53.3 kb | Distal (>10kb) Multiome | 831 | |
| chr8:42,541,069–42,542,355 | 203.2 kb | Distal (>10kb) Multiome | 767 | |
| chr8:42,571,247–42,571,811 | 233.0 kb | Distal (>10kb) Multiome | 205 |
Genomic view of the POLB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.